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Speakers, younger, healthier: a compelling human study on the shot of NMN

Uno Vita AS |

Improved vitality and health: a crucial human study on NMN supplementation

Research consensus indicates that high NAD levels in humans are beneficial, promote life and help prevent illness. Therefore, anti-aging researchers are constantly exploring strategies to increase the NAD levels as we grow older.

Supplementation of nicotinamide mononucleotide (NMN), a natural molecule that our bodies convert to NAD, can be such a method. Several studies correlate NMN intake with increased NAD levels, although correlation does not guarantee causation. Only animal studies confirmed the effect of NMN supplementation on increasing the NAD concentrations up to this groundbreaking human study.

An international research team tested the efficiency and safety of NMN supplementation in a clinical human study, published in the Geroscience Journal in December 2022. The comprehensive, multi-cooling study examined how different NMN doses affected NAD concentrations, NMN's tolerance and security, and its clinical effectiveness for of different assessments.

The gold standard randomized, double-blind, placebo-controlled, dose-dependent study involved 80 middle-aged (40-65 years) healthy adults. They were divided into three experimental groups and one placebo control group, each with 300, 600, or 900 mg of NMN oral daily.

This 60-day study involved thorough assessments, including safety and tolerance checks, NAD concentration measurement, endurance testing, "biological age" calculation, insulin resistance evaluation, and quality of life assessments.

The results indicated that NMN supplementation is safe and relatively tolerable with a significant increase in the NAD concentration. NMN also improved physical endurance, reduced "biological age", and improved participants' perceived quality of life and general health.

Interestingly, the study showed that a daily dosage of 600 mg resulted in significant improvements over 300 mg, but the increase of the dose to 900 mg provided no extra benefits. This study suggests that daily NMN supplementation can have a positive impact on general health, well-being, aging and endurance.

Generally about NMN
NMN (nicotinamidmonucleotide), a naturally produced molecule and nad-precursor, offer several health benefits, especially in aging and lifetime. Consumption of NMN supplements, available as powder or capsules, can potentially increase the NAD levels, leading to health improvements.

The main health benefits of NMN supplementation include:

  • Improved energy metabolism and physical endurance, counteract age -related energy decline.
  • Boosted brain health and memory, promotes protection of brain cells and better cognitive function while attenuating neurodegenerative diseases.
  • Improved heart health, causes blood pressure, improved cholesterol levels, and blood clot prevention to reduce the risk of cardiovascular disease.
  • Positive effects on diabetes and obesity, through better insulin sensitivity, blood sugar control, and reduction in inflammation and oxidative stress.
  • Skin rejuvenation, reduces aging signs such as wrinkles and hanging skin through collagen production and improved hydration.
  • Strengthened immune system, increases resistance to bacterial, viruses, or fungal infections.
  • Improved eye function, protects the eyes from damage caused by aging and light exposure, and improves the quality of vision.

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