Shikonin Pro Liposomal: Possible health effects and scientific documentation

Advantages and effects:
Shikonin Pro Liposomal combines natural shikonin with advanced pro liposomal technology to improve absorption. Shikonin, a bioactive compound extracted from Lithospermum erythrorhizon, has been studied for its biological interactions and potential to support the body's natural processes. This unique formulation provides high bioavailability and is free of unwanted additives.

What is Shikonin?

Shikonin is a naphthoquinone that has shown potential in supporting the body's natural functions. Traditionally used in East Asian medicine, modern research has focused on its antioxidant properties and its role in cellular processes such as inflammation regulation and tissue regeneration.

Possible health effects shown in studies:

1. Antioxidant protection:

   • Shikonin can help neutralize reactive oxygen species (ROS) and protect cells from oxidative stress.
   • Has shown the ability to reduce lipid peroxidation and protect DNA from oxidative damage.
     
     

2. Anti-inflammatory properties:

   • May inhibit the NF-κB signaling pathway, a key factor in inflammatory responses.
   • May help reduce pro-inflammatory cytokines such as TNF-α and IL-6.
     
     

3. Skin and tissue regeneration:

   • Shikonin can support keratinocyte migration, which promotes wound healing.
   • Has antibacterial properties that can prevent infections in wounds.
     
     

4. Support for Metabolic Health:

   • May help regulate glucose metabolism and improve insulin sensitivity.
   • Studies show that shikonin can reduce triglycerides and LDL cholesterol.
     
     

5. Function of the immune system:

   • Can contribute to balanced immune responses by modulating macrophages and natural killer cells (NK cells).
     
     

6. Advanced absorption with pro liposomal technology:
   Shikonin Pro Liposomal utilizes LongLifeLipoTech™ technology to maximize absorption. This creates neutrally charged liposomes using phospholipids and chitosan, which provides better bioavailability compared to traditional formulations.

Technical specifications:

• Ingredients: 30 mg shikonin per capsule from Lithospermum erythrorhizon extract. Pro liposomal blend (LongLifeLipoTech™): phospholipids from sunflower lecithin and mushroom chitosan. Vegan capsule (HPMC). No additives.
• Dosage: 1 capsule daily with plenty of water on an empty stomach, or as recommended by healthcare professionals.
• Packing: 120 ml glass container with 60 capsules.
• Storage: Store dry and cool.

Conclusion:
Shikonin Pro Liposomal is formulated to support the body's natural processes by combining shikonin with advanced liposomal technology. This unique formulation provides high absorption and is suitable for a healthy lifestyle. The product is free of additives and suitable for a vegan diet.

Disclaimer:
Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor.
The recommended daily dose should not be exceeded.
The effect of this product may vary from person to person.
Dietary supplements should not replace a varied diet.
Should be kept out of the reach of children.
Uno Vita AS does not claim that the products we market can cure disease.

References:

1. Sun, H., et al. (2015). Shikonin, a natural compound, exhibits anticancer activity by targeting multiple signaling pathways. Pharmacological Research, 102, 18-26.
2. Wei, W., et al. (2019). Shikonin inhibits NF-κB and MAPK signaling to attenuate inflammation. Frontiers in Pharmacology, 10, 1209.
3. Andújar, I., et al. (2013). Antioxidant and anti-inflammatory properties of shikonin: a systematic review. Food Chemistry, 141(4), 100-109.
4. He, W., et al. (2007). Shikonin induces keratinocyte migration and promotes wound healing. Journal of Dermatological Science, 45(2), 135-142.
5. Xu, H., et al. (2016). Liposomal formulations enhance the bioavailability of shikonin in animal models. International Journal of Nanomedicine, 11, 5595-5604.
6. Huang, Z., et al. (2020). Antioxidant effects of shikonin on oxidative stress in vitro. Oxidative Medicine and Cellular Longevity, 2020, 1-10.
7. Chen, H., et al. (2018). Shikonin improves lipid metabolism in animal models of dyslipidemia. Journal of Ethnopharmacology, 213, 57-65.
8. Wang, Y. et al. (2017). Immunomodulatory effects of shikonin on macrophages and NK cells. International Immunopharmacology, 49, 77-85.
9. Li, H., et al. (2015). Enhanced stability and bioavailability of shikonin via liposomal delivery systems. Journal of Controlled Release, 213, 152-160.
10. Wang, H., et al. (2021). Shikonin inhibits pro-inflammatory cytokines and promotes cellular repair. Biomedicine & Pharmacotherapy, 134, 111053.
11. Zhang, Q. et al. (2019). Role of shikonin in glucose homeostasis and metabolic health. Diabetes Research and Clinical Practice, 152, 107-113.
12. Fang, Y., et al. (2016). The molecular mechanisms underlying shikonin's anti-inflammatory effects. Inflammation Research, 65(10), 855-865.