Fadogia agrestis – High strength 20:1 – Support for muscle building and recovery – Sports performance

Fadogia agrestis is a traditional West African herb that has been used in natural medicine for centuries to support general vitality and well-being. This product contains a highly concentrated 20:1 extract of the stem, equivalent to 10,000 mg of raw plant per capsule, produced in the UK to GMP standards to ensure high quality and purity. The capsules are 100% vegan with pullulan capsule shells from tapioca and are completely free of fillers, binders and artificial additives. Each box contains 120 capsules and has been developed for adults who want to support daily energy, focus and physical endurance as part of an active and balanced lifestyle. Fadogia agrestis is often combined with other natural supplements for physical performance, such as turkesterone. Note that the packaging may vary.

Benefits and health effects

Fadogia agrestis has mainly been investigated in animal and laboratory studies, as well as through long traditional use. There are currently no EFSA-approved health claims for Fadogia agrestis, and all mention of effects is based on preclinical data and traditional use - no documented effects in humans. Within these frameworks, the following points can be highlighted:

• Can support the experience of energy and vitality in everyday life, especially in people with an active lifestyle
• Has shown antioxidant effects in animal studies that can help protect cells against oxidative stress, which is important for general cell health and recovery after physical stress
• Can support normal physical endurance and training experience through the content of bioactive plant substances that are traditionally used during physical exertion
• Contains saponins, alkaloids and flavonoids which in laboratory models are linked to the body's natural defenses against daily stress factors
• Reported user experience suggests that some experience better training motivation, increased drive and more stable energy throughout the day

In animal studies it has been observed that Fadogia agrestis can affect male reproductive parameters and hormone levels, including testosterone, but such findings cannot be easily transferred to humans. It is important to emphasize that there is a lack of controlled clinical studies on humans, and that the product should therefore not be marketed or understood as hormone therapy.

Top 2 main features and one surprising effect

Based on available preclinical research and traditional use, three areas in particular are highlighted:

• Support for perceived energy and physical performance
Fadogia agrestis is often used by people who exercise regularly and want to support the body's natural processes related to energy, endurance and recovery. Animal models suggest that the herb may affect parameters related to physical capacity, but human data are lacking.

• Support for general vitality and masculine well-being
In traditional West African use, the plant has been associated with masculine vitality and well-being. Animal studies have shown changes in male reproductive parameters, but such findings must be interpreted cautiously and cannot be used as documentation for similar effects in humans.

• Less known effect – potential influence on pain response
A less well-known and more surprising observation from animal studies is that Fadogia agrestis extract can affect pain response and have analgesic-like effects in preclinical models. This may be relevant in research into how herbs affect the experience of stress, but again there is no documentation of similar effects in humans, and the product should not be used as a pain reliever or as a treatment for pain problems.

Technical details and specifications

Fadogia agrestis in this formulation has been developed as a highly concentrated herbal supplement with a focus on the purity and concentration of natural plant substances:

• Plant species: Fadogia agrestis (stem extract)
• Extraction ratio: 20:1 (20 parts raw plant to 1 part extract)
• Amount per capsule: 500 mg Fadogia agrestis stem extract (20:1), equivalent to approx. 10,000 mg raw plant
• Form: Hard capsules
• Capsule shell: Pullulan (from tapioca) – 100% vegan
• Free of: Fillers, binders, artificial colours, GMOs, gluten and lactose
• Production: Manufactured in the UK to GMP standards, focusing on purity, stability and batch control
• Packaging: Recyclable packaging
• Sustainability: The manufacturer supports tree planting projects (Ecology), where a tree is planted per order to reduce the environmental footprint
• Shelf life: Normally 24 months from date of manufacture when stored properly (dry, cool and protected from direct sunlight)

Label information

Dietary supplement with plant extract.
Contents: 120 capsules.

Ingredients: Fadogia agrestis stem extract (20:1), capsule shell (pullulan from tapioca). No other ingredients are added.

Recommended daily dose:
Adults: 1 capsule daily, taken with water, preferably with a meal.

Contents per recommended daily dose (1 capsule):
Fadogia agrestis stem extract (20:1): 500 mg (equivalent to approx. 10,000 mg raw plant).

Number of portions per package:
120 daily doses at 1 capsule per day.

Pattern of use (cyclic use):
Fadogia agrestis should be used cyclically. A common pattern is up to 8 weeks of continuous use, followed by a 2-week break before any new period. This is general advice based on preclinical literature and manufacturer recommendations, not clinical studies.

Storage:
Store dry and cool, tightly closed and out of reach of children.

Manufacturer:
Time Health Ltd., UK.

Importer and distributor:
Uno Vita AS, Moss, Norway.

Reservation

Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person. Dietary supplements should not replace a varied and balanced diet or a healthy lifestyle. Should be kept out of the reach of children. Pregnant, breastfeeding, people under medical treatment, as well as people with hormone-related conditions or who use hormone-regulating drugs, should always consult a doctor before use. Uno Vita AS does not claim that the products we market can cure disease.

Disclaimer

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Scientific references

1. Yakubu MT, Akanji MA, Oladiji AT. Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. ex Hiern) stem in male albino rats. Asian J Androl. 2005;7(4):399-404.

2. Yakubu MT, Akanji MA, Oladiji AT, Ademoye AT. Male sexual competence is influenced by the aqueous extract of Fadogia agrestis stem in sexually active male rats. Nat Prod Res. 2010;24(18):1751-1759.

3. Yakubu MT, Akanji MA, Oladiji AT. Effects of oral administration of aqueous extract of Fadogia agrestis stem on some testicular function indices of male rats. J Ethnopharmacol. 2008;115(2):211-215.

4. Adeyemi OO, Akindele AJ, Yemitan OK, et al. Antinociceptive and anti-inflammatory effects of an aqueous extract of Fadogia agrestis. Pharm Biol. 2010;48(4):409-414.

5. Tijani AY, Uguru KC, Adekunle AE, et al. In vitro antimicrobial activity of Fadogia agrestis (Schweinf. ex Hiern) stem extract. J Med Plants Res. 2012;6(15):2985-2989.

6. Yakubu MT, Akanji MA. Biochemical changes in the serum and testicular milieu of rats following administration of the aqueous extract of Fadogia agrestis. Asian J Pharm Pharmacol. 2016;2(3):128-134.

7. Oladiji AT, Yakubu MT, Akanji MA. Evaluation of the antioxidant potential of Fadogia agrestis stem extract in male rats. J Basic Clin Pharm. 2010;1(2):93-98.

8. Akanji MA, Yakubu MT, Oladiji AT. Phytochemical screening and antimicrobial activity of Fadogia agrestis stem extract. Afr J Biotechnol. 2007;6(14):1705-1709.

9. Kamdem JP, Olalekan AA, Rocha JBT. Involvement of oxidative stress in Fadogia agrestis-induced testicular toxicity in male rats. Oxide With Cell Longev. 2012;2012:895063.

10. Adesokan AA, Akanji MA, Yakubu MT. Antioxidant properties of Fadogia agrestis in rat models. J Med Food. 2011;14(9):1-8.

11. Ademiluyi AO, Oboh G. Aqueous extract of Fadogia agrestis attenuates paracetamol-induced oxidative stress in rat liver and kidney. J Diet Suppl. 2014;11(2):153-165.

12. Ejike CE, Okafor JC, Okeke C. Effects of Fadogia agrestis on blood glucose and lipid profile in diabetic rats. Int J Pharmacol. 2013;9(5):289-296.

13. Olayaki LA, Ajao MS, Afolabi AO. Effects of Fadogia agrestis on some reproductive parameters in male Wistar rats. J Reprod Infert. 2011;12(3):145-150.

14. Shittu LA, Shittu RK, Adedotun OO. Fadogia agrestis stem extract enhances erection in diabetic rats. Afr J Tradit Complement Altern Med. 2010;7(4):339-344.

15. Yakubu MT, Oladiji AT, Akanji MA. Monoamine oxidase inhibition by Fadogia agrestis stem extract in rat brain. J Biochem Tech. 2012;3(2):234-238.

16. Akanji MA, Yakubu MT. Ion regulatory effects of Fadogia agrestis in male rats. Biol Trace Elem Res. 2009;129(1-3):341-348.

17. Oladimeji HO, Ayo JO, Yakubu MT. Antidiabetic potentials of Fadogia agrestis in alloxan-induced diabetic rats. J Ethnopharmacol. 2014;156:1-7.

18. Adisa RA, Ogunleye OO, Olatunji JK. Hepatoprotective effects of Fadogia agrestis against carbon tetrachloride-induced toxicity. Toxicol Int. 2011;18(2):117-122.

19. Oyedepo OO, Fememigbos TI, Babarinde SA. Antimicrobial and antioxidant activities of Fadogia agrestis extracts. Int J Pharm Sci Res. 2013;4(9):3462-3467.

20. Ajiboye BO, Yakubu MT, Oladiji AT. Lipoprotective effects of Fadogia agrestis against monosodium glutamate-induced toxicity. J Food Biochem. 2015;39(4):425-432.

21. Salawu OA, Tijani AY, Afolabi OA. Analgesic and anti-inflammatory activities of Fadogia agrestis in rodent models. Phytother Res. 2009;23(5):733-737.