What are NAD+ and NADH - and why are they important to the body?
NAD+ (nicotinamide adenin-dinucleotide) and NADH are essential biomolecules that play a crucial role in the body's energy production, DNA repair and general cellular function. They are involved in important processes such as glycolysis, the citric acid cycle and oxidative phosphorylation, where the energy from nutrients is converted to ATP (adenosinrifosphate), the body's primary source of energy.
Two forms of nad:
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Nad+ (oxidized form): An electron acceptor needed for energy production in metabolism. NAD+ is also important for activation of sirtuins, enzymes involved in aging, DNA repair and cellular health.
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Nadh (reduced form): When NAD+ accepts electrons, it is converted to NADH. NADH acts as an electron carrier in the mitochondria and is crucial for ATP production in the electron transport chain.
Why do the NAD+levels decrease with age?
Aging results in a natural decline in NAD+levels, which can lead to impaired cellular function, DNA repair and increased risk of age-related diseases such as diabetes, heart disease and neurodegenerative disorders. Research shows that NAD+levels can decrease by up to 50 % with increasing age.
How to increase NAD+levels?
There are several research-based strategies to increase NAD+levels, including supplements of NAD+extensions such as nicotinamidriboside (NR), nicotinamidmonucleotide (NMN), niacin (vitamin B3) and nicotinamide (NAM).
1. Nicotinamidriboside (no)
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Chemistry: No is a form of vitamin B3 that the body can quickly convert to NAD+.
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Effects: Improves mitochondrial function and energy metabolism, and is linked to anti-aging through the activation of sirtuins.
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Dosage: 300-2000 mg daily, with 1000 mg as a regular dose in clinical trials.
2. Nicotinamidmonucleotide (NMN)
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Chemistry: NMN is a direct precursor to NAD+ who is quickly converted into the body.
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Effects: Improves cognitive function, glucose metabolism and mitochondrial efficiency.
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Dosage: 250-500 mg daily, with some studies using up to 1250 mg without side effects. Liposomal formulations provide better recording.
3. Niacin B3 (nicotinic acid)
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Chemistry: A traditional form of vitamin B3 that is converted to NAD+.
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Effects: Useful to improve lipid metabolism and heart health, but can cause "blushing" at high doses.
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Dosage: 500-3000 mg daily, but higher doses can cause side effects.
4. Nicotinamide (NAM)
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Chemistry: Recycled to NAD+ through the "Salvage" road.
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Effects: Maintaining NAD+levels, but high doses can inhibit sirtuines.
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Dosage: 100-500 mg daily; Avoid doses above 1000 mg to avoid sirtuin inhibition.
Recommendation on the use of nadh
NADH is the energy-producing form of NAD+ and can be used immediately in ATP production. This makes NADH an ideal supplement for those who need an increase in energy or mental clarity.
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Dosage: 5-100 mg daily is safe and efficient.
Protocols for NAD+supplementation
A recommended protocol for high NAD+levels may include:
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Life Extension NAD+ Cell Regenerator: 300 mg no daily.
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Liposomal Methyl B-complex: 2 doses per day.
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NMN Restore Pro Liposomal: 1 dose daily.
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Nad+ Platinum: 2 doses daily.
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Nadh Constant: 20 mg daily for energy support.
Research on NAD+ in various health problems
NAD+ has shown potential in the treatment of several diseases, including neurodegenerative diseases (Alzheimer's, Parkinson's), Metabolic Diseases (Diabetes Type 2, Obesity) and Chronic Fatigue Syndrome. Increased NAD+levels can contribute to improved energy metabolism, cognitive function and prevention of age-related diseases.
Reservations for supplements and products:
This product is intended for adults. All use of supplements should be done at your own responsibilities and in consultation with a physician, especially with existing health problems or pregnancy. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person, and it is important to remember that supplements cannot replace a varied diet. Keep out of reach of children. Uno Vita AS does not claim that the products we market can cure, treat or prevent diseases.
General disclaimer:
Uno Vita AS is increasingly using artificial intelligence in analyzes, summaries and development of content for product descriptions and articles. We do not take responsibility for possible errors or inaccuracies due to human or technological errors (including AI). The information on this website is only for information purposes and is not intended to replace professional medical advice, diagnosis or treatment. All information and material offered are delivered "as it is" without guarantees, neither expressed nor implied, including, but not limited to, implicit guarantees of salarity or fitness for a particular purpose.
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Uno Vita AS reserves the right to share publicly available research and information on health and wellness technologies, natural substances and vitamins. This is done in accordance with national and international laws that ensure freedom of speech and freedom of belief, including:
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The UN World Declaration of Human Rights (1948), Article 19, which ensures the right to freedom of opinion and freedom of speech.
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