Red light therapy and photobiomodulation: A holistic approach to health with Uno Vita's RLPRO and RLPRO Max series

Red light therapy and photobiomodulation: A holistic approach to health with Uno Vita's RLPRO and RLPRO Max series

Summary
Red light therapy (RLT) and photobiomodulation (PBM) are innovative, non-invasive treatment methods that use specific wavelengths of red and near-infrared light to stimulate cellular processes, promote healing and support overall well-being. The technology has its roots in NASA research and early experiments in the 1960s, and has evolved to be used in medical, cosmetic and wellness-oriented contexts. PBM works by increasing ATP production in the mitochondria, reducing oxidative stress and modulating inflammation, which can contribute to improved skin health, pain relief, wound healing and potentially better sleep quality. Uno Vita, a leading player in integrated medicine in Norway, offers the RLPRO and RLPRO Max series of LED therapy lamps, which deliver precise wavelengths for targeted treatment. In addition, Uno introduces Vita Luci PHi, a new generation of full-body PBM panels with advanced frequency programs, which represent a significant advance in light therapy. This article provides a comprehensive overview of PBM's scientific basis, health benefits and technical details of Uno Vita's products.

Benefits and effects
Photobiomodulation has been studied for decades and offers a number of potential health effects, supported by scientific research. These effects are based on how light interacts with the body's cells, and results may vary between individuals. Below is a detailed review of the most documented benefits, formulated in line with EFSA guidelines to avoid medical claims:

Skin health
Red light in the wavelength range 630–670 nm is absorbed by skin cells and stimulates the production of collagen and elastin, which are essential proteins for the skin's structure and elasticity. This can help improve skin texture, reduce the appearance of fine lines and provide an even skin tone. Blue light (approx. 480 nm) has antibacterial properties that can support skin clarity in superficial skin problems, such as acne, by reducing bacterial growth and inflammation. A study published in Journal of Biomedical Optics showed that red light improved skin elasticity and collagen density in participants after eight weeks of treatment. Yellow light (590 nm) can also help reduce redness and promote a healthy skin glow. These effects make PBM a popular tool in cosmetic treatments, especially for those who want to support the skin's natural repair processes.

Pain relief
Near-infrared light (810-850 nm) penetrates deeper into the tissue and can support the body's natural processes to relieve muscle and joint discomfort. This happens through increased blood circulation, reduced inflammation and stimulation of nitric oxide production, which contributes to vasodilation. A meta-analysis in Photomedicine and Laser Surgery found that near-infrared light reduced pain and improved function in people with chronic joint pain, although the effect may vary. PBM can be a useful supplement for those seeking to support muscle and joint health, especially in connection with physical activity or chronic conditions.

Wound healing
PBM promotes cell proliferation and migration, which can accelerate the healing of wounds and damaged tissue. Increased ATP production and reduced oxidative stress play a central role in this process. Studies have shown that PBM can be particularly effective for superficial wounds and post-operative conditions, where faster repair is desired. A review in PMC highlighted PBM's ability to support tissue repair by increasing fibroblast activity and collagen synthesis, which is essential for restoring skin integrity.

Muscle recovery
By increasing blood circulation and reducing oxidative stress, PBM can support muscle recovery after physical activity. Near-infrared light can help reduce muscle stiffness and promote faster recovery by improving oxygen delivery to the muscles. A study in Journal of Athletic Training showed that PBM reduced muscle fatigue and improved performance in athletes, making it a popular tool in sports medicine. This can be particularly useful for people who exercise regularly or want to support muscle health.

Sleep and mood
Exposure to red light, especially in the evening, can help regulate the body's circadian rhythms by minimizing interference from blue light, which is often found in screens and artificial lighting. This can support better sleep quality and general relaxation. Some studies suggest that PBM may have an indirect positive effect on mood by reducing stress-related markers, but this requires further research to be fully confirmed. These effects may be particularly relevant for people who experience sleep disturbances or want to improve their mental well-being.

Cognitive support
A lesser known but promising effect is PBM's potential to support cognitive function. Near-infrared light can increase blood flow to the brain and reduce oxidative stress in neurons, which could theoretically improve mental clarity and focus. A study in Frontiers in Neuroscience suggested that transcranial PBM may have positive effects on cognitive processes, but this is still an area under active exploration and not an established health claim.

Anti-inflammatory effects
PBM reduces pro-inflammatory markers such as cytokines and increases nitric oxide production, which helps to reduce inflammation and support tissue repair. This can be an advantage in situations where inflammation affects general well-being. A review in PMC emphasized that both local and systemic mechanisms are involved, making PBM a versatile tool to support the body's natural processes.

General cellular health
Through increased ATP production and reduced oxidative stress, PBM can support the cells' normal functions. This includes activation of transcription factors that promote cell survival and repair, as well as stimulation of stem cell differentiation. These effects contribute to an overall improvement in the body's resilience and well-being, making PBM a valuable tool for those looking to support their overall health.

Surprising benefit
A lesser known benefit is PBM's potential to support cognitive function through transcranial application. Research suggests that near-infrared light can improve blood flow to the brain and reduce oxidative stress, which can have positive effects on memory and concentration. Although this is not an approved health claim, it is an exciting area for future research.

All of these benefits are based on general principles of how light interacts with the body, and results may vary between individuals. PBM is presented as a supplement to a healthy lifestyle, not as a substitute for medical treatment.

Technical specifications
Uno Vita's RLPRO and RLPRO Max series, as well as Luci PHi full-body PBM panels, are advanced devices designed to deliver targeted photobiomodulation. These products are designed to support the body's natural healing processes and offer a wide range of wavelengths and functions for both home use and professional environments. Below is a detailed description of each product range:

RLPRO series
The RLPRO series includes the RLPRO100, RLPRO200, RLPRO300 and RLPRO2000 models, which have been developed to meet different needs, from personal use to comprehensive professional treatments. Each model offers up to nine therapeutic wavelengths:

• 480 nm (blue light): Supports the treatment of superficial skin conditions by reducing bacterial growth and inflammation.

• 590 nm (yellow light): Helps to reduce redness and promote the skin's natural glow.

• 630 nm, 650 nm, 660 nm, 670 nm (red light): Stimulates collagen and elastin production, improves skin texture and reduces fine lines.

• 810 nm, 830 nm, 850 nm (near-infrared light): Penetrates deeper into muscles and joints to support pain relief and tissue repair.

• 1060 nm (long-wave near-infrared light): When deeper tissue layers for extensive therapeutic effects.

RLPRO100: A compact model ideal for home use, with a focus on skin health and smaller treatment areas.
RLPRO200: A medium-sized device that balances portability and power, suitable for both skin and muscle treatment.
RLPRO300: A larger model for more extensive treatments, popular in professional settings.
RLPRO2000: The most powerful model with 864 LEDs, designed for full body treatment and professional use.

Each unit is equipped with high-quality LED diodes that ensure even light distribution and high efficiency. Users can select specific wavelengths based on their needs, and the devices are intuitive with simple controls. Stand or foot must be ordered separately and users are encouraged to check specifications for each model.

RLPRO Max series
The RLPRO Max series, including the RLPRO300MAX and RLPRO450MAX, build on the RLPRO series by including adjustable pulse modes from 1 to 10,000 Hz. Pulsing improves light penetration and efficiency by modulating its delivery, providing additional flexibility:

• Low frequency pulses (1–10 Hz): Promotes relaxation and can reduce muscle tension, which is useful for pain relief and recovery.

• High-frequency pulses (100–10,000 Hz): Increases cellular stimulation and circulation, ideal for deep tissue treatment and energizing effects.

The Max series retains the wide range of wavelengths from the RLPRO series, but adds the possibility of customization through frequency adjustment. This makes them particularly suitable for professional users who want to tailor treatments to specific goals, such as pain relief or muscle recovery.

Luci PHi (Hue Light Whole Body PBM Panel)
Luci PHi, also known as Hue Light Whole Body PBM Panel, is a new generation of full body PBM panels developed in collaboration with Shenzhen Idea Light (Zidealight) and distributed by Uno Vita. Designed for professional clinics, gyms, spas, wellness centers and beauty clinics, these panels offer the following specifications:

• Wavelengths: Green (530 nm), Red (660 nm), Near-infrared (810–850 nm), Infrared (940 nm).

• LED light: 17,280 LEDs.

• Radiation strength: 55–90 mW/cm².

• Effect: 2000 W, requires 20 AMP connection.

• Processing time: 15–30 minutes per session, with a dose of 50–70 J/cm² for 10 minutes.

• Frequencies: Eight levels of adjustable Nogier frequencies.

• Control methods: Bluetooth compatible with smartphone app, WiFi, kiosk control.

• Adjustability: Height adjustable from 550 mm to 1150 mm via remote control, 360-degree rotation.

• Dimensions: 220 cm (L) x 106 cm (H) x 90 cm (W).

• Weight: 140 kg (308 lbs).

• Certifications: ISO 13485, CE medical, KFDA, FDA 510K registration.

• Warranty: 10-year warranty on the LED technology, 5-year general warranty.

The benefits include increased blood and lymph circulation, reduced muscle and joint pain, activation of ATP and mitochondria, anti-inflammatory effect and support for the immune system. The Luci PHi panels are ideal for full body treatment and represent a significant advance in light therapy by combining high intensity with extensive treatment options.

Comprehensive and detailed description
Photobiomodulation (PBM) is a technology that has evolved significantly since its origins in NASA research and early experiments in the 1960s. The scientific understanding of PBM is based on the interaction of light with cellular chromophores, especially cytochrome c oxidase in the mitochondria, which leads to increased ATP production, reduced oxidative stress and modulation of inflammation. These mechanisms make PBM a versatile tool to support the body's natural processes.

Scientific background
PBM works by light being absorbed by chromophores in the cells, which stimulates mitochondrial function and increases the production of adenosine triphosphate (ATP). This improves cellular metabolism, increases blood supply and reduces oxidative stress. Secondary effects include increased nitric oxide production, which has vasodilatory properties, and activation of transcription factors that support cell survival and repair. A review in PMC emphasized that both local and systemic mechanisms are involved, which means that light delivered to one area of the body can have positive effects on distant tissues and organs.

Skin health and cosmetic applications
Red light in the range 630–670 nm is particularly effective for skin health, as it stimulates fibroblast activity and collagen synthesis. This can help improve skin elasticity, reduce wrinkles and promote an even skin tone. Blue light (480 nm) has antibacterial properties that can support the treatment of acne by reducing bacterial growth and inflammation. Yellow light (590 nm) can help reduce redness and promote a healthy skin glow. A study in Journal of Biomedical Optics showed that red light improved skin elasticity and collagen density in participants after eight weeks of treatment, supporting the use of PBM in cosmetic treatments.

Pain relief and muscle recovery
Near-infrared light (810-850 nm) penetrates deeper into the tissue and can support pain relief by increasing blood circulation and reducing inflammation. A meta-analysis in Photomedicine and Laser Surgery found that near-infrared light reduced pain and improved function in people with chronic joint pain. For muscle recovery, PBM can reduce muscle soreness and promote faster recovery by improving oxygen delivery to the muscles. A study in Journal of Athletic Training showed that PBM reduced muscle fatigue and improved performance in athletes, making it a popular tool in sports medicine.

Wound healing and tissue repair
PBM promotes cell proliferation and migration, which can accelerate the healing of wounds and damaged tissue. Increased ATP production and reduced oxidative stress play a central role in this process. Studies have shown that PBM can be particularly effective for superficial wounds and post-operative conditions, where faster repair is desired. A review in PMC highlighted the ability of PBM to support tissue repair by increasing fibroblast activity and collagen synthesis.

Sleep and mood
Exposure to red light in the evening can help regulate the body's circadian rhythms by minimizing interference from blue light. This can support better sleep quality and general relaxation. Some studies suggest that PBM may have an indirect positive effect on mood by reducing stress-related markers, but this requires further research to be fully confirmed.

Cognitive support
The potential of PBM to support cognitive function is an exciting area under exploration. Near-infrared light can increase blood flow to the brain and reduce oxidative stress in neurons, which could theoretically improve mental clarity and focus. A study in Frontiers in Neuroscience suggested that transcranial PBM can have positive effects on cognitive processes, but this is not an established health claim.

Anti-inflammatory effects
PBM reduces pro-inflammatory markers such as cytokines and increases nitric oxide production, which helps to reduce inflammation and support tissue repair. A review in PMC emphasized that both local and systemic mechanisms are involved, making PBM a versatile tool to support the body's natural processes.

General cellular health
Through increased ATP production and reduced oxidative stress, PBM can support the cells' normal functions. This includes activation of transcription factors that promote cell survival and repair, as well as stimulation of stem cell differentiation. These effects contribute to a general improvement of the body's resilience and well-being.

Controversies and limitations
While PBM has shown promising results, there is still debate about its effectiveness for certain conditions. Some critics, such as Paul Ingraham of Pain Science, argue that PBM may be overhyped, and that sunlight already provides similar benefits. There is also disagreement about optimal wavelengths and doses, especially for treating the brain, where only a small fraction of the light reaches the target. Many studies are funded by companies that sell PBM devices, which can affect objectivity. Users should approach exaggerated claims with caution and consult a healthcare professional to assess benefits and risks.

Disclaimer and reservations
Use of devices such as the RLPRO and RLPRO Max series, as well as the Luci PHi panels, should be done in consultation with qualified healthcare personnel. These products are not intended to replace medical treatment or to prevent, treat or cure disease. Keep out of the reach of children. Uno Vita AS does not claim that the products can cure disease.

Freedom of expression and right to information
Uno Vita reserves the right to share publicly available research on health and wellness technologies in accordance with national and international freedom of expression laws, including:

• UN Universal Declaration of Human Rights (1948), Article 19: The right to freedom of opinion and expression.

• International Covenant on Civil and Political Rights (1966), Article 19: Freedom to seek, receive and impart information.

• Norwegian Constitution § 100: Protection of freedom of expression.

• The United States' First Amendment: Protection of freedom of speech against government interference.

References

1. Photobiomodulation—Underlying Mechanism and Clinical Applications. PMC. 2020. https://pmc.ncbi.nlm.nih.gov/articles/PMC7356229/

2. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. PMC. 2017. https://pmc.ncbi.nlm.nih.gov/articles/PMC5523874/

3. Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation. PMC. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11049838/

4. Red Light Therapy: Effectiveness, Treatment, and Risks. WebMD. 2024. https://www.webmd.com/skin-problems-and-treatments/red-light-therapy

5. Red Light Therapy: Benefits, Side Effects & Uses. Cleveland Clinic. 2023. https://my.clevelandclinic.org/health/articles/22114-red-light-therapy

6. How it works — Photobiomodulation Therapy. Photobiomodulation Studio. https://photobiomodulationstudio.uk/how-it-works

7. FoundMyFitness Topic - Red light therapy (photobiomodulation). FoundMyFitness. https://www.foundmyfitness.com/topics/photobiomodulation

8. The Hype Around Photobiomodulation. McGill University. 2023. https://www.mcgill.ca/oss/article/medical-critical-thinking/hype-around-photobiomodulation

9. Photobiomodulation: The Clinical Applications of Low-Level Light Therapy. PubMed. 2021. https://pubmed.ncbi.nlm.nih.gov/33471046/

10. The Effects and Mechanisms of PBM Therapy in Accelerating Orthodontic Tooth Movement. Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/7/1140

11. The effects of photobiomodulation therapy on inflammatory mediators, immune infiltration, and angiogenesis in a mouse model of rosacea. Ann Transl Med. 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9442505/

12. The effect of different treatment protocols with diode laser on regeneration in axonetmesis injuries of the inferior alveolar nerve: an animal study. Lasers Med Sci. 2023. https://pubmed.ncbi.nlm.nih.gov/37515606/