Improved Vitality and Health: A Conclusive Human Study on NMN Supplementation
Research consensus indicates that high NAD levels in humans are beneficial, promoting longevity and helping to prevent disease. Therefore, anti-aging researchers are continually exploring strategies to increase NAD levels as we age.
Supplementation of Nicotinamide Mononucleotide (NMN), a natural molecule that our bodies convert to NAD, can be one such method. Several studies correlate NMN intake with increased NAD levels, although correlation does not guarantee causation. Only animal studies confirmed the effect of NMN supplementation on increasing NAD concentrations until this groundbreaking human study.
An international research team tested the efficacy and safety of NMN supplementation in a human clinical study, published in the GeroScience Journal in December 2022. The comprehensive, multigoal study investigated how different NMN doses affected NAD concentrations, NMN's tolerability and safety, and its clinical effectiveness using different assessments.
The gold standard randomized, double-blind, placebo-controlled, dose-dependent study involved 80 middle-aged (40-65 years) healthy adults. They were divided into three experimental groups and a placebo control group, each with 300, 600, or 900 mg of NMN orally daily.
This 60-day study involved thorough assessments, including safety and tolerability checks, NAD concentration measurement, endurance testing, "biological age" calculation, insulin resistance evaluation, and quality of life assessments.
The results indicated that NMN supplementation is safe and relatively tolerable with significant increases in NAD concentration. NMN also improved physical endurance, reduced "biological age", and improved participants' perceived quality of life and overall health.
Interestingly, the study showed that a daily dosage of 600 mg provided significant improvements over 300 mg, but increasing the dose to 900 mg provided no additional benefits. This study suggests that daily NMN supplementation may have a positive impact on overall health, well-being, aging and endurance.
General about NMN
NMN (nicotinamide mononucleotide), a naturally produced molecule and NAD precursor, offers several health benefits, especially in aging and longevity. Consuming NMN supplements, available as powders or capsules, can potentially increase NAD levels, leading to health improvements.
The main health benefits of NMN supplementation include:
- Improved energy metabolism and physical endurance counteract age-related energy decline.
- Boosted brain health and memory, promotes protection of brain cells and better cognitive function while at the same time suppressing neurodegenerative diseases.
- Improved heart health, resulting in regulation of blood pressure, improved cholesterol levels, and prevention of blood clots to reduce the risk of cardiovascular disease.
- Positive effects on diabetes and obesity, through better insulin sensitivity, control of blood sugar, and reduction in inflammation and oxidative stress.
- Skin rejuvenation, reduces signs of aging such as wrinkles and sagging skin through collagen production and improved hydration.
- Strengthened immune system, increases resistance to bacterial, viral or fungal infections.
- Improved eye function, protects the eyes from damage caused by aging and light exposure, and improves the quality of vision.
