Unlocking the potential of NMN (nicotinamide mononucleotide) for improved health and longevity

Nicotinamide mononucleotide (NMN) is an intrinsic compound found in all living cells. It acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme central to a number of cellular processes, including energy metabolism, DNA repair and cellular protection.

As we age, NAD+ levels naturally decline, and this decline has been associated with various age-related diseases such as Alzheimer's disease, Parkinson's disease, and cardiovascular conditions.

NMN supplementation has shown the capacity to raise NAD+ levels in both animal studies and human trials, sparking growing interest in their potential health benefits.

Here are some of the potential health benefits associated with NMN:

Improved cognitive function: NMN has shown the potential to improve cognitive function in animal models of Alzheimer's and Parkinson's diseases. Human studies have also suggested that NMN supplementation may improve memory and cognitive function in older adults.

Reduced risk of heart disease: NMN has shown cardioprotective properties in animal models, reducing the risk of heart disease. Some human studies have indicated that NMN supplementation may improve heart function and reduce the risk of cardiovascular problems.

Improved muscle function: NMN has been shown to improve muscle function and reduce muscle atrophy in animal models. Human studies have also indicated that NMN supplementation can increase muscle function and strength, particularly in older adults.

Potential for increased lifespan: Animal models have shown extended lifespan with NMN supplementation. While more research is needed, some human studies have suggested that NMN supplementation may have positive effects on longevity.

The potential health benefits of NMN are the subject of ongoing research and exploration. As our understanding of NMN continues to evolve, it holds promise as a tool to improve health and extend our years of vitality.

Sources:

Health line: NMN (nicotinamide mononucleotide): benefits, side effects and dosage
Health news: NMN benefits: How good are NMN dietary supplements
Youth & Earth: The Ultimate Guide to NMN (Nicotinamide Mononucleotide)
NOVOS: 8 powerful antiaging benefits of NMN | Science of longevity
Yunique Medical: 7 important health benefits of NMN and its side effects

Improved Vitality and Health: A pivotal human trial of NMN supplementation

Research consensus indicates that high NAD levels in humans are beneficial, promoting longevity and aiding disease prevention. Therefore, antiaging researchers are continually exploring strategies to raise NAD levels as we age.

Nicotinamide mononucleotide (NMN) supplementation, a natural molecule that our bodies convert to NAD, can be one such method. Numerous studies correlate NMN intake with increased NAD levels, although correlation does not guarantee causation.

Only animal studies confirmed NMN supplementation's effect on increasing NAD concentrations until this game-changing human trial.

An international research team tested the efficacy and safety of the NMN supplement in a human clinical study, published in the GeroScience Journal in December 2022. The comprehensive, multi-target study investigated how different NMN doses affected NAD concentrations, NMN's tolerability and safety, and its clinical efficacy. by means of various assessments.

The gold standard randomized, double-blind, placebo-controlled, dose-dependent study involved 80 middle-aged (40-65 years) healthy adults. They were divided into three experimental groups and a placebo control group, each receiving 300, 600 or 900 mg of NMN orally daily.

This 60-day study involved rigorous assessments, including safety and tolerability checks, NAD concentration measurement, endurance testing, "biological age" calculation, insulin resistance assessment, and quality of life evaluations.

The results indicated that NMN supplementation is safe and relatively tolerable with significant increases in NAD concentration. NMN also improved physical endurance, reduced "biological age" and increased the participants' perceived quality of life and general health.

Interestingly, the study showed that a daily dose of 600 mg provided significant improvements over 300 mg, but increasing the dose to 900 mg provided no additional benefit. This study suggests that daily NMN supplementation may have a positive impact on overall health, well-being, aging and endurance.

General about NMN
NMN (nicotinamide mononucleotide), a naturally produced molecule and NAD precursor, offers several health benefits, especially in aging and longevity. Consuming NMN supplements, available as powder or capsules, can potentially increase NAD levels, leading to health improvements.

Key health benefits of NMN supplementation include:

  • Improved energy metabolism and physical endurance, which counteracts age-related energy decline.
  • Increased brain health and memory, promotes protection of brain cells and better cognitive function while reducing neurodegenerative diseases.
  • Improved heart health, which involves blood pressure regulation, improved cholesterol levels and prevention of blood clots to reduce the risk of cardiovascular disease.
  • Positive effects on diabetes and obesity, through better insulin sensitivity, blood sugar control and reduction in inflammation and oxidative stress.
  • Skin rejuvenation, reduces signs of aging such as wrinkles and laxity via collagen production and hydration.
  • Strengthened immune system, strengthens resistance to bacterial, viral or fungal infections.
  • Improved eye function, protects the eyes against aging and light exposure, thus improving the quality of vision.