Optimized Folate L-Methylfolate – 1700 mcg DFE – 100 Vegetable Tablets

Optimized folate is a dietary supplement with 5-MTHF (L-methylfolate), the biologically active form of vitamin B9 that the body can use directly without enzymatic conversion. The product has been developed for adults who want to support normal homocysteine ​​metabolism, blood formation, psychological function and the normal function of the immune system. The formulation is gluten-free, non-GMO and 100% vegetable 🌿

Each tablet contains a high concentration of L-methylfolate, and the product is therefore intended to portioned in accordance with Norwegian/EU regulations for reference intake (RI), not used as a whole tablet daily without professional guidance.

Physiological role and documented function

Folate is an essential vitamin that is part of the body's one-carbon metabolism and is necessary for DNA synthesis, methylation, amino acid synthesis and cell division. L-methylfolate (5-MTHF) is the form that actually circulates in plasma and is used in the cells, thereby bypassing limitations in the conversion of synthetic folic acid in some individuals 🧬

Unlike folic acid, L-methylfolate does not require activation via the MTHFR enzyme before it has a biological effect, which makes this form particularly relevant where folate metabolism may be impaired (professional background).

Health effects (EFSA-approved claims for folate)

• Contributes to normal homocysteine metabolism
• Contributes to normal psychological functioning and to reduce fatigue and exhaustion
• Contributes to normal blood formation
• Contributes to normal function of the immune system
• Contributes to normal amino acid synthesis
• Has a role in the cell division process

These effects apply when taken in line with the recommended reference intake and as part of a varied diet.

Top 2 main functions and one professionally interesting feature

• Homocysteine and vascular/brain health 🧠
Folate contributes to the normal turnover of homocysteine, an established biomarker used in the assessment of cardiovascular and neurological health (EFSA).

• Blood formation and cognitive support 🩸
Folate is necessary for normal erythropoiesis and psychological function, and is part of central metabolic processes in the nervous system.

• Academically interesting feature ✨
5-MTHF can be taken up directly in folate metabolism without having to be converted from folic acid, which may be relevant in case of reduced enzyme activity or increased folate requirement (professional background, not health claim).

Technical details and specifications

Statutory designation: Dietary supplement with vitamin B9 (folate)
Form: Vegetable tablets
Quantity: 100 tablets
Properties: Gluten-free, non-GMO, vegetable

Content per tablet

• Folate: 1700 mcg DFE
- corresponding to approx. 1,000 mcg folate
- like (6S)-5-methyl-tetrahydrofolate, calcium salt (L-methylfolate)

Recommended use – Norwegian/EU adapted dosage

Reference intake (RI) for folate in the EU/Norway: 200 mcg/day

• Recommended Norwegian daily dose: 1/10 tablet daily
- corresponds to approx. 170 mcg DFE
- approx. 85% of RI

Practical options:
• Divide the tablet into 10 and take 1/10 daily
• Divide by 5 and take 1/5 tablet every other day (≈ 170 mcg DFE on average per day)

Use beyond this should only take place in consultation with qualified healthcare personnel.

Other ingredients

Microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.

Allergens: None known
Suitable for vegetarians and vegans

Reservations and security

• At risk of vitamin B12 deficiency healthcare professionals should be consulted, as high folate intake may mask haematological signs of B12 deficiency ⚠️
• Do not exceed the recommended daily dose
• Pregnant women, breast-feeding women and people undergoing medical treatment should consult a doctor
• Dietary supplements should not replace a varied and balanced diet or a healthy lifestyle
• Keep out of the reach of children

Uno Vita AS does not claim that the product can prevent, treat or cure disease.

Disclaimer

Uno Vita AS uses manufacturer data, publicly available research and artificial intelligence when designing product information. Errors, changes in regulations or updates to the scientific knowledge base may occur. The information is only intended as general information and does not replace medical advice, diagnostics or treatment. All use is at your own risk.

Freedom of expression and right to information

Uno Vita AS reserves the right to disseminate publicly available research and knowledge about vitamins, nutrition and health in line with Section 100 of the Constitution, Article 19 of the UN Universal Declaration of Human Rights and Article 19 of the SP Convention.

Scientific references

1. EFSA NDA Panel. Scientific opinions on folate health claims.

2. EU Register of Nutrition & Health Claims (Reg. 432/2012).

3. Regulation (EU) 1169/2011 – NRV/RI for folate (200 μg).

4. Obeid R et al. Folate and vitamin B12 metabolism. Nutrients, 2021.

5. Smith AD, Refsum H. Homocysteine and cardiovascular risk. Lancet, 2020.

6. Crider KS et al. Folate and DNA methylation. Adv Nutr, 2012.

7. Bailey SW, Ayling JE. Conversion of folic acid to active folate. J Nutr Biochem, 2009.

8. Pietrzik K et al. 5-MTHF vs folic acid. Clin Pharmacokinet, 2010.

9. Lamers Y et al. Bioavailability of 5-MTHF. Am J Clin Nutr, 2006.

10. McNulty H et al. Homocysteine ​​and B vitamins. Am J Clin Nutr, 2008.

11. Strain JJ et al. B vitamins and cognition. Proc Nutr Soc, 2013.

12. Clarke R et al. Folate, B12 and cognitive decline. Am J Clin Nutr, 2007.

13. Green R. Vitamin B12 deficiency and folate. Hematology, 2017.

14. De Vriese SR et al. Folate and neural function. Nutrients, 2012.

15. Reynolds E. Folate and neuropsychiatric disorders. Lancet, 2006.

16. Miller JW. Folate and neurocognition. Nutr Rev, 2008.

17. Stover PJ. One-carbon metabolism and brain health. Am J Clin Nutr, 2011.

18. Brouwer IA et al. Folate intake and homocysteine. Am J Clin Nutr, 1999.

19. Wald DS et al. Homocysteine ​​lowering with folic acid. BMJ, 2002.

20. Pfeiffer CM et al. Folate biomarkers and DFE conversion. Am J Clin Nutr, 2012.