Nattokinase – Nattiase® – 2000 FU / 100 mg – Fermented soybean extract – Support for normal circulation

Nattokinase is a natural enzyme extracted from traditional Japanese natto – soybeans fermented with the bacterium Bacillus subtilis var. night. Natto has been part of the Japanese diet for over 1,000 years and is known both as a food and as a source of concentrated, natural nutrients. This product contains Nattiase®, a world-leading, radiation-free nattokinase ingredient type from fermented soybean extract, standardized to 2000 fibrinolytic units (FU) per capsule. The enzyme is encapsulated in stomach acid-resistant DRcaps™ capsules, which have been developed to release the contents further down the digestive tract. The product is 100% vegan, with no fillers, binders or artificial additives, and is manufactured in the UK to GMP standards. Nattokinase is used by many adults who want a plant-based enzyme supplement as part of daily support for normal circulation and general well-being. The manufacturer also supports tree planting projects through Ecology, so that a tree is planted for every order.

Benefits and health effects

There are several human studies and review articles that have examined nattokinase in connection with factors such as blood flow, blood pressure and coagulation-related markers, but there are no EFSA-approved health claims for nattokinase specifically. The product should therefore be understood as a dietary supplement for general health and well-being, not as treatment or prevention of disease. Within these frameworks, the following properties and potential benefits can be described based on research and biochemical mode of action:

• Nattokinase is a proteolytic enzyme that can help support the body's own mechanisms to maintain normal blood flow by breaking down proteins such as fibrin in laboratory and animal models
• Studies in humans have shown that nattokinase can affect markers of coagulation and fibrinolytic activity, such as fibrinogen and selected coagulation factors, which is interpreted as supporting normal circulatory physiology in healthy adults
• Clinical studies have examined nattokinase in connection with parameters such as blood pressure and certain cardiometabolic risk factors, but the results are variable, and there is no basis for medical claims - nevertheless, the findings suggest that nattokinase may be relevant as part of a holistic lifestyle that also includes diet, activity and follow-up with a doctor
• Nattokinase from fermented soybean extract additionally provides a supplement from a traditional food (natto) which in observational studies has been linked to good cardiovascular health in Japanese populations, without being able to conclude about a causal relationship
• Many user experiences describe a subjective experience of "lighter" legs, better comfort when sitting still and general well-being when nattokinase is included as part of a healthy lifestyle - these are individual experiences and not documented health claims

Top 2 main features and one lesser known effect

Based on published research and overview articles (without these being approved health claims), there are three areas in particular that are highlighted in the specialist literature:

• Support for normal blood flow and circulation
Clinical studies have shown that nattokinase can affect fibrinolytic markers in humans, including by reducing levels of fibrinogen and selected coagulation factors, which is considered relevant to normal blood fluidity and circulatory physiology.PubMed+1

• Examined in connection with normal blood pressure values
Randomized, controlled trials have investigated nattokinase in adults with mildly elevated blood pressure values and reported moderate reductions in mean blood pressure compared to placebo.PubMed+1 These findings are interpreted as interesting, but are not grounds for claiming that a dietary supplement treats high blood pressure.

• Lesser known effect - research into neurobiological and ageing-related mechanisms
Recent laboratory and animal studies have looked at nattokinase in connection with proteins that can form deposits in tissues (for example in the brain) and other aging-related mechanisms.MDPI+1 This is early, experimental research that cannot be transferred directly to humans, but which makes nattokinase interesting in further research into healthy aging and the cellular environment.

Technical details and specifications

The nattokinase product from Nattiase® has been developed as a targeted enzyme supplement with standardized activity:

• Active substance: Nattiase® nattokinase – enzyme from fermented soybean extract (Glycine max)
• Enzyme activity: 2,000 FU (fibrinolytic units) per capsule (100 mg nattokinase with 20,000 FU/g)
• Enzyme type: Serine protease with fibrinolytic activity (proven in vitro and in animal models)PMC+1
• Capsule type: DRcaps™ – stomach acid-resistant capsules of HPMC (hydroxypropylmethylcellulose) adapted to delayed release
• Excipient: Alfalfa in small quantities to ensure even filling and capsule production
• Free of: Vitamin K2, fillers, binders, artificial colors and flavorings
• Allergen information: Contains soy (from fermented soybean extract)
• Suitability: 100% vegan, non-GMO, gluten-free and lactose-free according to manufacturer information
• Production: Manufactured in the UK to GMP standards and relevant quality control for dietary supplements
• Packaging: 60 or 120 capsules in a recyclable container
• Shelf life: Usually 24 months from date of manufacture when stored dry, cool and protected from direct sunlight

Label information

Designation
Dietary supplement with nattokinase from fermented soybean extract.

Content per capsule
Nattiase® nattokinase (from fermented soybean extract): 100 mg
Enzyme activity: 2000 FU (fibrinolytic units)
Capsule shell: DRcaps™ (hydroxypropylmethylcellulose)

Other ingredients
Alfalfa (for capsule filling).

Recommended daily dose
Adults: 1 capsule daily, swallowed whole with water, preferably with a meal, or as recommended by a qualified healthcare professional.

Number of portions per package
• 60 capsules: up to 60 days of use at 1 capsule daily
• 120 capsules: up to 120 days of use with 1 capsule daily

Allergens
Contains soy. Not suitable for people with a soy allergy.

Storage
Store dry and cool, tightly closed and out of reach of children.

Manufacturer
Time Health Ltd., UK.

Importer and distributor
Uno Vita AS, Moss, Norway.

Reservation

Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person. Dietary supplements should not replace a varied and balanced diet or a healthy lifestyle. Should be kept out of the reach of children. Pregnant, breastfeeding, people with bleeding disorders or people on prescription drugs, especially drugs that affect blood coagulation (for example, blood thinners), should always consult a doctor before use. Nattokinase is an enzyme that can affect the blood's coagulation ability, and the authorities have pointed out the need for medical follow-up when combined with such drugs. Uno Vita AS does not claim that the products we market can cure disease.

Disclaimer

Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles and product descriptions. We do not accept responsibility for possible errors in texts, articles or descriptions due to human or computer technology (AI-related) errors, inaccuracies or missing information in scientific and medical studies. We encourage all readers to examine all information critically to ensure that the content is correct, up-to-date and relevant to their own situation. Uno Vita does not claim medical effects of the products we sell, but refers to publicly available research in accordance with the right to freedom of expression. The information on this website is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. The content must not be used as a basis for making diagnoses or choosing forms of treatment. All information and materials on this website are provided "as is" without any warranties, either expressed or implied, including, but not limited to, implied warranties of merchantability, fitness for a particular purpose or non-infringement. Uno Vita disclaims all responsibility for loss or damage that may arise as a result of the use of information or products from this website. We strongly recommend that you consult a qualified healthcare professional before starting any new treatment, making significant changes to your diet or using nutritional supplements. All use of products or information from this website is at your own risk.

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Uno Vita reserves the right to share publicly available research and information on health and wellness technologies, natural substances, vitamins, enzymes, plant extracts and the like. This is done with reference to national and international laws and principles on freedom of expression and information, including the UN Universal Declaration of Human Rights (1948), article 19, the International Convention on Civil and Political Rights (1966), article 19, Norway's Constitution § 100 and the USA's First Amendment. Uno Vita reserves the right to freedom of opinion and expression in line with these principles.

Scientific references

1. Kim JY et al. Effects of nattokinase on blood pressure: A randomized, controlled trial. Hypertension Res. 2008;31(8):1583–1588. 

2. Hsia CH et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29(3):190–196. 

3. Li X et al. Nattokinase supplementation and cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled trials. Rev. Cardiovasc Med. 2023;24(8):234. Jensen GS et al. Consumption of nattokinase is associated with reduced blood pressure and other cardiovascular benefits in humans. Integra Blood Pressure Control. 2016;9:95–104.

4. Wu H et al. Nattokinase as a functional food ingredient: therapeutic applications and challenges. Curr Opin Food Sci. 2024;53:101089. 

5. Chen H et al. Nattokinase: A promising alternative in prevention and treatment of cardiovascular diseases. Integr With Res. 2018;7(2):1–11. 

6. Fang M et al. Nattokinase: Insights into biological activity, therapeutic potential and food applications. Fermentation. 2023;9(11):950. 

7. Fujita M et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18(10):1387–1391. 

8. Kurosawa Y et al. A single dose of nattokinase enhances fibrinolytic activity in healthy adults. J Nutr Sci Vitaminol. 2015;61(4):357–362.

9. Li W et al. Nattokinase supplementation improves carotid artery elasticity in middle-aged adults: A pilot study. Clin Hemorheol Microcirc. 2020;75(3):339–348. 

10. Ren NN et al. Effects of nattokinase on blood lipid profile in adults with elevated lipids: A randomized trial. Chin J Clin Pharmacol. 2017;31(4):363–368. 

11. Sumi H et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese natto. Experience. 1987;43(10):1110–1111. 

12. Li X et al. Cardiovascular efficacy of nattokinase on risk factors: A meta-analysis. Rev. Cardiovasc Med. 2023;24(8):e8234.

13. Ashokan AK et al. Therapeutic potential of fibrinolytic enzymes with focus on nattokinase. SN Appl Sci. 2025;7(2):102–115.

14. EFSA Panel on Nutrition. Safety of fermented soybean extract NSK-SD® as a novel food. EFSA J. 2016;14(7):4541. 

15. Japan Nattokinase Association. Safety details and human studies on nattokinase. j-nattokinase.org (accessed 2025). 

16. Li Z et al. Nattokinase and vascular health: effects on endothelial function and arterial stiffness. Hypertension Res. 2019;42(8):1189–1197

17. Park KJ et al. Nattokinase supplementation and arterial stiffness in middle-aged adults. Clin Hemorheol Microcirc. 2020;75(3):351–360

18. Zhang X et al. Nattokinase reduces amyloid-beta accumulation in experimental models. J Agric Food Chem. 2022;70(8):2567–2576. 

19. HumanClinicals.org. Nattokinase clinical summaries and outcome measures (fibrinogen, factor VII, factor VIII). humanclinicals.org (accessed 2025). 

20. Li Q et al. Nattokinase for cardiovascular risk modulation: an updated narrative review. Curr Cardiol Rev. 2024;20(1):1–15.