Life Extension Mitochondrial Energy Optimizer with PQQ - support for energy, heart and brain
Life Extension Mitochondrial Energy Optimizer with PQQ is an advanced dietary supplement formulated to support mitochondrial function, energy metabolism and the cells' defense against oxidative stress. The formula combines PQQ (pyrroloquinoline quinone), R-lipoic acid, carosine, taurine, benfotiamine, luteolin and vitamin B6 (P-5-P) in vegetarian capsules. The product is non-GMO and gluten-free.

Summary
The purpose is to support the body's "energy factories" (the mitochondria), contribute to protection against oxidative stress and support the normal functions of the heart and brain through known nutrients and bioactive compounds. PQQ and R-lipoic acid are mentioned in the research for roles in mitochondrial biogenesis and redox balance, while carosine and benfotiamine have been studied in connection with glycation control. Taurine and P-5-P are involved in amino acid and neurotransmitter metabolism. (See regulatory notes for Norway/EEA below.)

Health effects
• Promotes the cells' energy production through nutritional support for mitochondrial biochemistry (PQQ, R-lipoic acid).
• Contributes to the cells' antioxidant defense and redox balance in everyday life (R-lipoic acid, luteolin, PQQ).
• Supports cardiovascular and neurological function via amino acid and coenzyme-related processes (taurine, P-5-P, benfotiamine).
• Helps the body's handling of glycation-related reactions in tissues (carosin, benfotiamine - mechanistic background).

Top 2 main features and 1 surprise effect
• Energy and vitality ⚡
Support for the mitochondria's function (PQQ, R-lipoic acid) as part of normal energy metabolism.
• Cellular protection 🛡️
Bioactive antioxidant compounds (R-lipoic acid, luteolin) support the cells' defense against oxidative stress.
• Surprising advantage ✨
The combination carosin + benfotiamine is often used in research on glycation control – an aspect that affects both the skin, vessels and nervous system (informative, not a medical claim).

Technical details and specifications
Form: Vegetarian capsules.
Number of capsules: 120.
Suggested use from the manufacturer: 2 capsules, 2 times a day without food (preferably early in the day or taken together upon waking).

Supplement facts (given per daily dose from manufacturer: 4 capsules)
• PQQ (pyrroloquinoline quinone), disodium salt: 10 mg
• R-lipoic acid (stabilized Na-RALA): 150 mg
• Carnosine: 1000 mg
• L-taurine: 800 mg
• Benfotiamine: 150 mg
• Vitamin B6 (pyridoxal-5′-phosphate): 100 mg
• Luteolin (from orange extract): 8 mg
Other ingredients: Vegetable cellulose (capsule), microcrystalline cellulose, stearic acid, silica, hydroxypropyl cellulose, candelilla wax, beeswax.

Disclaimer and disclaimer (dietary supplements)
Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person. Dietary supplements should not replace a varied diet. Keep out of the reach of children. Uno Vita AS does not claim that the products we market can cure disease.
Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles. We do not accept responsibility for possible errors in texts, articles or descriptions due to human or computer technology (AI) errors, inaccuracies or missing information in scientific and medical studies. The information is not intended to replace professional medical advice, diagnosis or treatment. All use is at your own risk.

Freedom of expression and right to information
Uno Vita reserves the right to share publicly available research and information on health and wellness technologies, natural substances, vitamins and the like, in line with: UN Universal Declaration of Human Rights (1948) Article 19, International Convention on Civil and Political Rights (1966) Article 19, Norwegian Constitution § 100, US First Amendment.

Scientific references

1. EFSA NDA Panel. Tolerable Upper Intake Level for Vitamin B6 (2023).

2. EFSA. Union list of permitted health claims & NRV/RI (Reg. 1169/2011; 432/2012).

3. EFSA. Safety assessment/authorisation of PQQ as novel food (2017–2018).

4. Chowanadisai W, et al. PQQ stimulates mitochondrial biogenesis via CREB/PGC-1α. J Biol Chem, 2010.

5. Rucker R, et al. PQQ and mitochondrial function. Altern Med Rev, 2009.

6. Hou Y, et al. Nutritional modulation of mitochondrial function. Cell Metab, 2019.

7. Packer L, et al. R-alpha-lipoic acid in redox balance and mitochondria. Free Radic Biol Med, 1995.

8. Shay KP, et al. Alpha-lipoic acid as dietary supplement. Biochim Biophys Acta, 2009.

9. Schaffer SW, et al. Taurine and cardiovascular function. Amino Acids, 2014.

10. Ripps H, Shen W. Review of taurine's physiological role. Exp Eye Res, 2012.

11. Boldyrev AA, et al. Carnosine as antioxidant and antiglycation agent. Rejuvenation Res, 2013.

12. Hipkiss AR. Carnosine and protein carbonylation/glycation. Mech Aging Dev, 2008.

13. Baye E, et al. Benfotiamine in diabetic complications. Diabetes Metab, 2017.

14. Balakumar P, et al. Benfotiamine and AGEs. Pharmacol Res, 2010.

15. Parohan M, et al. Luteolin and inflammation/oxidative stress (review). Clin Nutr ESPEN, 2021.

16. Seelinger G, et al. Anti-carcinogenic effects of luteolin. Mol Nutr Food Res, 2008.

17. Swerdlow RH. Mitochondria and aging. J Gerontol A, 2018.

18. Mailloux RJ. Mitochondrial bioenergetics and oxidative stress. J Biochem Mol Toxicol, 2014.

19. Ames BN. Mitochondrial decay in aging. PNAS, 2019.

20. Morieri ML, et al. Vitamin B6 and neuropathy risk—dose considerations. Nutrients, 2023.

21. BfR opinions/round-ups on "other substances" (R-lipoic acid, taurine) - safety context in foods/supplements.