Optimized Folate L-Methylfolate – 1700 mcg DFE, 100 Veggie Tablets
Optimized folate contains 5-MTHF (L-methylfolate) – the biologically active form of folate that the body can use directly without conversion. The product has been developed for adults who want to support normal homocysteine ​​metabolism, blood formation and psychological function, and is gluten-free, non-GMO and vegetable.

Summary
Each tablet contains 1700 mcg DFE (≈ 1000 mcg folate as (6S)-5-methyl-tetrahydrofolate, calcium salt). For Norwegian/EU labeling and compliance with the reference value (RI) of 200 mcg/day, a Norwegian daily dose of 1/10 tablet daily (≈ 170 mcg DFE, approx. 85% RI) is recommended. The tablet can be divided with tablet parts/crushed and portioned (practical tip: divide into 5 and take 1/5 every other day, or divide into 10 for 1/10 daily). Health personnel can provide guidance in case of special needs.

Health effects
• Contributes to normal homocysteine metabolism (EFSA approved for folate)
• Contributes to normal psychological function and reduces fatigue and exhaustion (EFSA)
• Contributes to normal blood formation and the normal function of the immune system (EFSA)
• Contributes to normal amino acid synthesis and tissue growth in pregnant women (EFSA) – the latter is information for the target group, not a recommendation for use
• High bioavailability: 5-MTHF (L-methylfolate) bypasses genetic/enzymatic limitations (e.g. MTHFR variants) that can affect the conversion of folic acid to the active folate form (professional background)

Top 2 main features and surprising effect
• Homocysteine and heart/vessels 🧬: Folate contributes to normal homocysteine metabolism, a biomarker for heart and brain health (EFSA).
• Blood formation and cognitive support 🧠: Folate contributes to normal blood formation and psychological function (EFSA).
• Surprising advantage ✨: 5-MTHF can be taken up directly in folate metabolism without having to be activated - useful in case of reduced folate synthesis/conversion (professional background).

Technical details and specifications
Statutory designation: Dietary supplement with vitamin B9 (folate).
Portion size (Norwegian daily dose): 1/10 tablet (≈ 170 mcg DFE ≈ 85% RI).
Contents per tablet: Folate 1,700 mcg DFE [as (6S)-5-methyl-tetrahydrofolate, calcium salt] (≈ 1,000 mcg folate).
Suggested use (manufacturer): 1 tablet daily with food.
Norwegian/EU adapted use (according to the RI requirement): 1/10 tablet daily (≈ 170 mcg DFE). Alternatively, 1/5 tablet can be taken every other day (≈ 340 mcg DFE every other day ≈ 170 mcg DFE on average per day).
Other ingredients: Microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.
Allergens: None known. Gluten-free, non-GMO, plant-based.

Reservations and security
• Important: At risk of vitamin B12 deficiency healthcare professionals should be consulted – high folate intake may mask haematological signs of B12 deficiency.
• Adults: Keep out of the reach of children. Do not exceed the recommended daily dose. Pregnant/nursing women or people undergoing medical treatment should consult a doctor.
• Dietary supplements must not replace a varied and balanced diet or a healthy lifestyle.

Disclaimer
Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles. We do not accept responsibility for possible errors due to human or computer technology (AI) errors, inaccuracies or missing information in studies. The information is not intended to replace professional medical advice, diagnosis or treatment. All use is at your own risk. Uno Vita AS does not claim that our products can cure disease.

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Scientific references

1. EFSA NDA. Scientific opinions on folate health claims (homocysteine, fatigue, psychological function, blood formation, immune function).

2. EU Register of Nutrition & Health Claims (Reg. 432/2012): approved claims for folate.

3. Regulation (EU) 1169/2011: NRV/RI for folate (=200 μg/day).

4. Obeid R, et al. Folate and vitamin B12 metabolism in the elderly. Nutrients/Reviews, 2021.

5. Smith AD, Refsum H. Homocysteine and cardiovascular risk. Lancet, 2020.

6. Crider KS, et al. Folate and DNA methylation. Adv Nutr, 2012.

7. Bailey SW, Ayling JE. The extremely slow conversion of folic acid to active form. J Nutr Biochem, 2009.

8. Pietrzik K, et al. 5-MTHF vs folic acid—bioavailability and safety. Clin Pharmacokinet, 2010.

9. Lamers Y, et al. Bioavailability of 5-MTHF versus folic acid. Am J Clin Nutr, 2006.

10. McNulty H, et al. Homocysteine, B-vitamins and vascular health. Am J Clin Nutr, 2008.

11. Strain JJ, et al. B-vitamins and cognition in ageing. Proc Nutr Soc, 2013.

12. Clarke R, et al. Folate, B12 and homocysteine ​​in cognitive decline. Am J Clin Nutr, 2007.

13. Green R. Vitamin B12 deficiency and folate—diagnostic interactions. Hematology, 2017.

14. De Vriese SR, et al. Folate and neural function. Nutrients, 2012.

15. Reynolds E. Folate and neuropsychiatric disorders. Lancet, 2006.

16. Miller JW. Folate and neurocognition. Nutr Rev, 2008.

17. Stover PJ. One-carbon metabolism and brain health. Am J Clin Nutr, 2011.

18. Brouwer IA, et al. Folate intake and homocysteine: dose–response. Am J Clin Nutr, 1999.

19. Wald DS, et al. Homocysteine ​​lowering with folic acid. BMJ, 2002.

20. EFSA Scientific Opinion on Tolerable Upper Intake Levels for folate (as folic acid) – context note.

21. Pfeiffer CM, et al. Folate biomarkers and DFE conversions. Am J Clin Nutr, 2012.