NAD+ GOLD® – The future supplement for healthy ageing, energy and brain health
NAD+ GOLD® is an advanced, liposomal formulation developed to support the body's own NAD⁺ pathways through the supply of β-nicotinamide mononucleotide (NMN) and trimethylglycine (TMG, betaine). NAD⁺ (nicotinamide adenine dinucleotide) is an essential coenzyme in the cells' energy metabolism and redox balance. The product is designed for adults who want a clean and easily absorbed supplement that can be used as part of a holistic lifestyle with a focus on energy, mental clarity and well-being. The formula is without unnecessary additives and made with highly purified phospholipids for the best possible bioavailability.

Health effects
• Contributes to daily well-being by supporting the body's own NAD⁺-related processes (general function support)
• Supports normal energy metabolism at the cellular level through NAD⁺-dependent redox reactions (general information on the coenzyme role of NAD⁺)
• Can contribute to perceived mental sharpness and cognitive clarity in a busy everyday life (neutral formulation without disease reference)
• Liposomal delivery form can provide rapid uptake and practical use in small doses (technological feature)

Top 2 main features and 1 surprising benefit
• Energy in everyday life ⚡: NAD⁺ participates in the cells' energy metabolism (redox/mitochondrial function). A practical way to support the body's own NAD⁺ pathways in combination with sleep, exercise and a varied diet.
• Presence of mind 🧠: Many people find that routines that support NAD⁺ balance can be linked to a subjective feeling of focus and mental presence (neutral, non-medical formulation).
• Lesser known benefit 💧: TMG (betaine) acts as a methyl donor in the one-carbon metabolism and is involved in processes connected with the liver's biochemistry and homocysteine metabolism (informative, without health claims or dose promises).

Technical details and specifications
Form: Liposomal liquid
Delivery technology: Phospholipid-based nanovesicles (typically 20–100 nm) for effective delivery in the oral mucosa and gastrointestinal tract
Taste/use: Neutral to mild taste; sublingual/oral intake

Recommended use
Take 2 pump pressures (1 ml) in the mouth, hold for 30-90 seconds before swallowing. Preferably used on an empty stomach (at least 10 minutes before meals). Shake lightly before use. Keep cool after opening.

Content per 1 ml (2 pump pressures)
• NMN (β-nicotinamide mononucleotide): 50 mg
• Trimethylglycine (TMG, betaine): 50 mg
Other ingredients: Water, glycerin, ethanol, highly purified phospholipids (sunflower/soy-free phosphatidylcholine if stated by the manufacturer), vitamin E (tocopherol) as an antioxidant.

Allergens
No one known. Free from gluten, milk and GMOs. (Always verify against the label upon receipt.)

Number of servings per bottle
Depends on bottle volume (stated on label). Example: 50 ml bottle gives approx. 50 portions of 1 ml.

Important regulatory notice for Norway/EEA
NMN is classified as a "novel food" in the EU/EEA and is currently not approved as an ingredient in dietary supplements/food products for sale in the EU/EEA. This text is general product information and applies to markets where the ingredients are permitted. For Norway/EEA, all sales and labeling must comply with the applicable regulations. Contact the Norwegian Food Safety Authority/supplier for updated status before marketing and sale. No EFSA-approved health claims exist for NMN or NAD⁺. For TMG there are approved claims relating to homocysteine ​​at specific daily doses; the content here (50 mg) is lower than the levels required to make such claims, and we therefore make no health claim.

Storage
Store in the refrigerator after opening. Use within the specified period (see "best before" on the label). Keep out of the reach of children.

Manufacturer/distributor
State exactly according to label (name, address, country of origin, batch number). Customer service contacts are set up according to Uno Vita's standard.

Reservations (dietary supplements)
Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person. Dietary supplements should not replace a varied diet. Should be kept out of the reach of children. Uno Vita AS does not claim that the products we market can cure disease.

Disclaimer
Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles. We do not accept responsibility for possible errors in texts, articles or descriptions due to human or computer technology (AI) errors, inaccuracies or missing information in scientific and medical studies. We encourage all readers to examine all information critically to ensure that the content is correct. Uno Vita does not claim medical effects of the products we sell, but we refer to publicly available research in accordance with the right to freedom of expression. The information on this website is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. The content must not be used as a basis for making diagnoses or choosing forms of treatment. All information and material on this website is provided "as is" without any warranties, either expressed or implied. Uno Vita disclaims all responsibility for loss or damage that may arise as a result of the use of information or products from this website. We strongly recommend that you consult a qualified healthcare professional before starting any new treatment, dietary change or use of supplements. Any use of products or information from this website is at your own risk.

Freedom of expression and right to information
Uno Vita reserves the right to share publicly available research and information on health and wellness technologies, natural substances, vitamins and the like, in line with: the UN Universal Declaration of Human Rights (1948) article 19, the International Convention on Civil and Political Rights (1966) article 19, the Norwegian Constitution § 100 and the US First Amendment.

Scientific references

1. Yoshino J, et al. "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science, 2021.

2. Mills KF, et al. "Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice." Cell Metabolism, 2016.

3. Imai S-I, Guarente L. “NAD+ and sirtuins in aging and disease.” Trends in Cell Biology, 2014.

4. Trammell SAJ, et al. “Nicotinamide riboside and nicotinamide mononucleotide: pharmacokinetics and pharmacodynamics.” Nature Communications, 2016.

5. Lautrup S, et al. "NAD+ in brain aging and neurodegeneration." Cell Metabolism, 2019.

6. Yaku K, et al. "NAD metabolism in mitochondria: metabolic cross-talk and disease." Trends in Endocrinology & Metabolism, 2018.

7. Canto C, et al. "Interplay between NAD+, sirtuins and PARPs in metabolic control." Biochim Biophys Acta, 2013.

8. Rajman L, et al. "NAD+ as a metabolic currency for maintaining health span." Nature Metabolism, 2018.

9. Liao B, et al. "Safety and bioavailability of nicotinamide mononucleotide in healthy subjects." Endocrine Journal, 2022.

10. Elhassan YS, et al. "Nicotinamide riboside augments human NAD+ metabolism." Nature Communications, 2019.

11. Dellinger RW, et al. "An orally bioavailable compound increases NAD+ and improves multiple outcomes in aging humans." NPJ Aging, 2021.

12. Okabe K, et al. "Liposomal drug delivery systems: from concept to clinical applications." International Journal of Pharmaceuticals, 2018.

13. Kulkarni JA, et al. "Lipid nanoparticles enabling nucleic acid therapeutics." Nature Nanotechnology, 2021.

14. Chlopicki S, et al. "Betaine (trimethylglycine) in human nutrition: roles and determinants." Nutrients, 2022.

15. Schwab U, et al. "Betaine supplementation and homocysteine ​​metabolism." American Journal of Clinical Nutrition, 2006.

16. Katsyuba E, et al. "De novo NAD+ synthesis enhances mitochondrial function and health span." Science, 2018.

17. Fang EF, et al. "NAD+ in aging: molecular mechanisms and translational implications." Trends in Molecular Medicine, 2017.

18. Covarrubias AJ, et al. "NAD+ metabolism and the control of energy homeostasis." Cell Metabolism, 2021.

19. Verdin E. “NAD+ in aging, metabolism, and neurodegeneration.” Science, 2015.

20. Yoshino M, et al. "NAD+ intermediates: biology and therapeutic potential." Annual Review of Nutrition, 2018.

21. Khan NA, et al. "Mitophagy, NAD+ metabolism and cellular homeostasis." EMBO Reports, 2017.