AHCC® 500 mg – 60 capsules (MCS Formulas)
AHCC® is a standardized extract from shiitake mycelium (Lentinula edodes) developed in Japan. The raw material is produced via a patented fermentation and enzyme process that provides partially acetylated alpha-glucans and a lower molecular weight for the best possible absorption. The product comes in vegan capsules, is tested for purity by independent laboratories and comes from the original manufacturer of AHCC® in Japan.

Health benefits
• In the literature, AHCC® has been investigated for its influence on parameters related to immune response (eg changes in T cells/NK cells and interferon markers) in both animals and humans.
• AHCC® has also been studied in connection with general well-being under stress, where tolerance and recovery-related markers have been the subject of several publications.
• Less well known: In recent clinical research, an interesting correlation has been reported between a decrease in interferon-beta (IFN-β) to below certain levels and more favorable immune markers in participants who received AHCC®—a research finding that has triggered further studies on duration and follow-up.

Technical details / specifications
Raw material: AHCC® (Active Hexose Correlated Compound), standardized extract from shiitake mycelium
Standardization: At least 10% alpha-glucans (partially acetylated)
Production: Patented Japanese process with controlled fermentation and enzymatic modification (lower molecular weight)
Capsule: Hypromellose (vegan)
Free from: Yeast, wheat, gluten, soya, milk, eggs, fish, shellfish and tree nuts (not added)
Packaging: Glass (approx. 120 ml)
Net content: 60 capsules × 500 mg = 30 g
Recommended use: Adults take 1–2 capsules twice a day with food, or as agreed with a healthcare professional

Label information (ingredients, amounts, allergens, daily dose, RI, portions, storage, manufacturer/importer)
Statutory designation: Dietary supplement
Ingredients: AHCC® proprietary blend (shiitake mycelium extract (Lentinula edodes), rapeseed oil (process engineering), dextrin (carrier), microcrystalline cellulose (filler), alpha-cyclodextrin (carrier)); capsule: hypromellose
Recommended daily dose: 2–4 capsules (1,000–2,000 mg AHCC®), divided into 2 doses and taken with food
Content per daily dose: AHCC® 1,000–2,000 mg (reference intake (RI) not established)
Number of portions per package: Approx. 15–30 days with recommended use
Allergens: No declared allergens added
Storage: Dry and cool (<25 °C), tightly closed, inaccessible to children. Do not use if seal is broken
Origin of active raw material: Japan (Amino Up Co., Ltd.)
Brand/packaging: MCS Formulas (EU)
Importer/responsible business in the EEA: Uno Vita AS, Norway (address/contact appears on the label)
Batch/Lot and "best before": Stated on the packaging

Reservation
Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect may vary from person to person. Dietary supplements should not replace a varied and balanced diet or a healthy lifestyle. Keep out of the reach of children. Uno Vita AS does not claim that the products we market can cure disease.

Disclaimer
Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles. We do not accept responsibility for possible errors in texts, articles or descriptions due to human or computer technology (AI) errors, inaccuracies or missing information in scientific and medical studies. The information is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Freedom of expression
Uno Vita reserves the right to share publicly available research and information on health and wellness technologies, natural substances, vitamins and the like, in line with the UN Universal Declaration of Human Rights (Article 19), the International Covenant on Civil and Political Rights (Article 19), the Constitution § 100 and the US First Amendment.

Scientific references

1. Smith JA et al. AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections. Frontiers in Oncology, 2022.

2. Smith JA et al. From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk HPV. Frontiers in Oncology, 2019.

3. Gao Y et al. Active Hexose Correlated Compound Enhances Tumor Surveillance Through Innate and Adaptive Responses. Cancer Immunol Immunother, 2006.

4. Uno K et al. AHCC Improves Immunological Parameters and Performance Status of Patients with Solid Tumors. Biotherapy, 2000.

5. Nogusa S et al. Low-Dose AHCC Improves the Immune Response to Acute Influenza Infection in Mice. Nutrition Research, 2009.

6. Hirose A et al. Influence of AHCC on Cisplatin-Evoked Chemotherapeutic Side Effects in Tumor-Bearing Mice. Toxicol Appl Pharmacol, 2007.

7. Ishibashi H et al. Prophylactic Efficacy of AHCC Against Lethal Opportunistic Infections in Mice. Yakugaku Zasshi, 2000.

8. Matsui Y et al. Improved Prognosis of Postoperative Hepatocellular Carcinoma Patients Treated with AHCC. Journal of Hepatology, 2002.

9. Yanagimoto H et al. Immunostimulatory Effects of AHCC in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrition Research, 2016.

10. Hunter RJ et al. Evaluation of AHCC with Pegylated Liposomal Doxorubicin for Ovarian Cancer. Int J Appl Res Nat Prod, 2011.

11. Yang Y et al. Anti-Tumor Activity of Alpha-Glucan from Shiitake Mycelium. Int J Biol Macromol, 2011.

12. Wilson EB et al. Blockade of Chronic Type I Interferon Signaling to Control Persistent Viral Infection. Science, 2013.

13. Teijaro JR et al. Persistent Viral Infection Controlled by Blockade of Type I Interferon Signaling. Science, 2013.

14. Maeda Y, Tokuda H. Anti-Inflammatory Effects of Shiitake-Derived Fractions. Food Science and Biotechnology, 1996.

15. Gao Y et al. Immunomodulating Effects of AHCC: Enhanced Activation of CD4+/CD8+ T Cells and NK Cells. (review article)

16. Ritz BW et al. Supplementation with AHCC Enhances Immune Response in Mice. (preclinical)

17. Zhang Y, Yamamoto T. Clinical Implications of AHCC in Therapy: Immunological and Clinical Effects. Nutrition Reviews, 2018.

18. Kouttab N et al. Enhancement of Natural Killer Cell Activity in Rats Fed with AHCC. Immunology Letters, 1991.

19. Ito T et al. Anti-Tumor and Immunomodulating Activities of AHCC in Animal Models. Int Immunopharmacol, 1999.

20. Miura T et al. Basic and Clinical Studies on AHCC. In: Biotechnology in Functional Foods and Nutraceuticals, 2010.

21. Doorbar J. Host Control of Human Papillomavirus Infection and Disease. Best Practice & Research Clinical Obstetrics & Gynaecology, 2018.