Longevitality - a science-based nutritional supplement for well-being and a long life

Longevitality is a premium "biohacking" and anti-aging dietary supplement that combines five bioactive compounds – nicotinamide riboside (NR), trans-resveratrol, honokiol, fisetin and astaxanthin – in a carefully formulated blend. These ingredients are obtained from natural sources and have been thoroughly studied in research into cellular metabolism, mitochondrial function and oxidative stress. The product has been developed for those who want to support the body's natural processes with high-quality, plant-based substances without additives. Each daily dose (two capsules) contains 200 mg NR, 100 mg trans-resveratrol, 100 mg honokiol, 100 mg fisetin and 8 mg astaxanthin, packed in 100% vegan capsules. Longevitality is produced with a focus on purity and efficiency, and is free from gluten, soy, milk and other allergens.

Longevitality contains a unique composition of five natural bioactive substances, each of which helps to support the body's functions in different ways. Here, their general effects are described based on scientific research, without making medical claims:

• Nicotinamide riboside (NR) contributes to the production of NAD+, a coenzyme essential for cellular energy metabolism. NAD+ plays an important role in the function of the mitochondria and supports the body's natural energy metabolism. Research shows that NR is an efficient and bioavailable source of NAD+, which is involved in many enzymatic processes related to general cell health.

• Trans-resveratrol is a polyphenol found naturally in grapes and other plants. It is known to support the cells' protection against oxidative stress, a process in which antioxidants help neutralize free radicals. Studies have explored its interaction with sirtuin 1 (SIRT1), an NAD+-dependent enzyme family involved in cellular homeostasis and stress response.

• Honokiol, extracted from the bark of Magnolia species, is a lignan with documented properties in mitochondrial research. It has been shown to interact with sirtuin 3 (SIRT3), which helps to maintain the normal function of mitochondria. This can support the body's ability to deal with cellular stress and maintain a healthy balance in the cells.

• Fisetin is a flavonoid found in strawberries, apples and other fruits. It is recognized for its antioxidant properties, which can help protect cells from damage caused by oxidative stress. Research has also explored its role in supporting the body's natural processes related to cellular ageing, without directly linking this to specific diseases.

• Astaxanthin, a carotenoid from marine algae, is known for its strong antioxidant properties. It helps to protect the cells against oxidative stress and supports the skin's general nutrition through its provitamin A activity. EFSA has approved the health claim that vitamin A helps to maintain normal skin, which makes astaxanthin a valuable supplement in this context.

Overall, Longevitality offers a synergistic blend of ingredients that support the body's natural processes, including energy production, cell protection and mitochondrial function. The product is ideal for those who want to incorporate science-based, natural substances into their daily routine for overall health and well-being.

Technical details and specifications

• Daily dose: 2 capsules

• Number of capsules per container: 60

• Content per daily dose:

  • Nicotinamide riboside (NR): 200 mg

  • Trans-resveratrol: 100 mg

  • Honokiol: 100 mg

  • Fisetin: 100 mg

  • Astaxanthin (organic): 8 mg

• Other ingredients: Vegan capsule (HPMC), no additives.

• Free for: Yeast, wheat, gluten, soya, milk, eggs, fish, shellfish, nuts.

• Storage: Store dry and cool in original packaging.

• Recommended use: 1 capsule twice daily with water with meals.

• Packaging: 120 ml glass container.

Scientific references

1. Bogan, K. L., & Brenner, C. (2008). Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition.

2. Baur, J. A., & Sinclair, D. A. (2006). Therapeutic potential of resveratrol: The in vivo evidence.

3. Wood, J.G., et al. (2004). Sirtuin activators mimic caloric restriction and delay aging in metazoans.

4. Yousefzadeh, M.J., et al. (2018). Fisetin is a senotherapeutic that extends health and lifespan.

5. Kidd, P. M. (2009). Astaxanthin, cell membrane nutrient with various clinical benefits and anti-aging potential.