NAD supplements and NADH in therapy - what, how and why?

What are NAD+ and NADH – and why are they important for the body?

NAD+ (nicotinamide adenine dinucleotide) and NADH are essential biomolecules that play a crucial role in the body’s energy production, DNA repair, and general cellular function. They are involved in important processes such as glycolysis, the citric acid cycle, and oxidative phosphorylation, where energy from nutrients is converted into ATP (adenosine triphosphate), the body’s primary energy source.

Two forms of NAD:

• NAD+ (oxidized form): An electron acceptor that is necessary for energy production in metabolism. NAD+ is also important for the activation of sirtuins, enzymes involved in aging, DNA repair, and cellular health.

• NADH (reduced form): When NAD+ accepts electrons, it is converted into NADH. NADH functions as an electron carrier in the mitochondria and is crucial for ATP production in the electron transport chain.

NAD supplements for aging and energy

Why do NAD+ levels decline with age?

Aging causes a natural decline in NAD+ levels, which can lead to impaired cellular function, DNA repair, and an increased risk of age-related diseases such as diabetes, heart disease, and neurodegenerative disorders. Research shows that NAD+ levels can decline by up to 50% with increasing age.

How to increase NAD+ levels?

There are several research-based strategies for increasing NAD+ levels, including supplementation with NAD+ precursors such as Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Niacin (vitamin B3), and Nicotinamide (NAM).

1. Nicotinamide Riboside (NR)

• Chemistry: NR is a form of vitamin B3 that the body can quickly convert into NAD+.

• Effects: Improves mitochondrial function and energy metabolism, and is associated with anti-aging through activation of sirtuins.

• Dosage: 300-2000 mg daily, with 1000 mg as a common dose in clinical studies.

2. Nicotinamide Mononucleotide (NMN)

• Chemistry: NMN is a direct precursor to NAD+ that is rapidly converted in the body.

• Effects: Improves cognitive function, glucose metabolism, and mitochondrial efficiency.

• Dosage: 250-500 mg daily, with some studies using up to 1250 mg without side effects. Liposomal formulations provide better absorption.

3. Niacin B3 (Nicotinic acid)

• Chemistry: A traditional form of vitamin B3 that is converted into NAD+.

• Effects: Useful for improving lipid metabolism and heart health, but may cause "flushing" at high doses.

• Dosage: 500-3000 mg daily, but higher doses may cause side effects.

4. Nicotinamide (NAM)

• Chemistry: Recycled into NAD+ through the "salvage" pathway.

• Effects: Maintains NAD+ levels, but high doses may inhibit sirtuins.

• Dosage: 100-500 mg daily; avoid doses above 1000 mg to prevent sirtuin inhibition.

Recommendation on the use of NADH

NADH is the energy-producing form of NAD+ and can be used immediately in ATP production. This makes NADH an ideal supplement for those who need an increase in energy or mental clarity.

• Dosage: 5-100 mg daily is safe and effective.

Protocols for NAD+ supplementation

A recommended protocol for high NAD+ levels may include:

• Life Extension NAD+ Cell Regenerator: 300 mg NR daily.

• Liposomal Methyl B-Complex: 2 doses per day.

• NMN RESTORE Pro Liposomal: 1 dose daily.

• NAD+ Platinum: 2 doses daily.

• NADH Constant: 20 mg daily for energy support.

Research on NAD+ in various health conditions

NAD+ has shown potential in the treatment of several diseases, including neurodegenerative diseases (Alzheimer's, Parkinson's), metabolic diseases (type 2 diabetes, obesity), and chronic fatigue syndrome. Increased NAD+ levels may contribute to improved energy metabolism, cognitive function, and the prevention of age-related diseases.

Reservation regarding supplements and products:

This product is intended for adults. All use of supplements should take place at your own responsibility and in consultation with a physician, especially in cases of existing health issues or pregnancy. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person, and it is important to remember that supplements cannot replace a varied diet. Keep out of reach of children. Uno Vita AS does not claim that the products we market can cure, treat, or prevent diseases.

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