What are NAD+ and NADH - and why are they important for the body?
NAD+ (nicotinamide adenine dinucleotide) and NADH are essential biomolecules that play a crucial role in the body's energy production, DNA repair and general cellular function. They are involved in important processes such as glycolysis, the citric acid cycle and oxidative phosphorylation, where the energy from nutrients is converted into ATP (adenosine triphosphate), the body's primary energy source.
Two forms of NAD:
-
NAD+ (oxidized form): An electron acceptor that is necessary for energy production in metabolism. NAD+ is also important for the activation of sirtuins, enzymes involved in aging, DNA repair and cellular health.
-
NADH (reduced form): When NAD+ accepts electrons, it is converted to NADH. NADH acts as an electron carrier in the mitochondria and is essential for ATP production in the electron transport chain.
Why do NAD+ levels decline with age?
Aging causes a natural decline in NAD+ levels, which can lead to impaired cellular function, DNA repair and increased risk of age-related diseases such as diabetes, heart disease and neurodegenerative disorders. Research shows that NAD+ levels can decrease by up to 50% with increasing age.
How to increase NAD+ levels?
There are several research-based strategies to increase NAD+ levels, including supplementation of NAD+ precursors such as Nicotinamide Riboside (NR), Nicotinamide Mononucleotide (NMN), Niacin (Vitamin B3), and Nicotinamide (NAM).
1. Nicotinamide riboside (NR)
-
Chemistry: NR is a form of vitamin B3 that the body can quickly convert to NAD+.
-
Effects: Improves mitochondrial function and energy metabolism, and is linked to anti-aging through activation of sirtuins.
-
Dosage: 300-2000 mg daily, with 1000 mg as the usual dose in clinical studies.
2. Nicotinamide mononucleotide (NMN)
-
Chemistry: NMN is a direct precursor to NAD+ which is quickly converted in the body.
-
Effects: Improves cognitive function, glucose metabolism and mitochondrial efficiency.
-
Dosage: 250-500 mg daily, with some studies using up to 1250 mg without side effects. Liposomal formulations provide better absorption.
3. Niacin B3 (Nicotinic acid)
-
Chemistry: A traditional form of vitamin B3 that is converted to NAD+.
-
Effects: Useful for improving lipid metabolism and heart health, but can cause "flushing" at high doses.
-
Dosage: 500-3000 mg daily, but higher doses can cause side effects.
4. Nicotinamide (NAM)
-
Chemistry: Recycled to NAD+ through the "salvage" pathway.
-
Effects: Maintains NAD+ levels, but high doses may inhibit sirtuins.
-
Dosage: 100-500 mg daily; avoid doses above 1000 mg to avoid sirtuin inhibition.
Recommendation on the use of NADH
NADH is the energy-producing form of NAD+ and can be immediately used in ATP production. This makes NADH an ideal supplement for those who need a boost in energy or mental clarity.
-
Dosage: 5-100 mg daily is safe and effective.
Protocols for NAD+ supplementation
A recommended protocol for high NAD+ levels may include:
-
Life Extension NAD+ Cell Regenerator: 300 mg NR daily.
-
Liposomal Methyl B-Complex: 2 doses per day.
-
NMN RESTORE Pro Liposomal: 1 dose daily.
-
NAD+ Platinum: 2 doses daily.
-
NADH Constant: 20 mg daily for energy support.
Research on NAD+ in various health problems
NAD+ has shown potential in the treatment of several diseases, including neurodegenerative diseases (Alzheimer's, Parkinson's), metabolic diseases (type 2 diabetes, obesity) and chronic fatigue syndrome. Increased NAD+ levels can contribute to improved energy metabolism, cognitive function and prevention of age-related diseases.
Reservations for dietary supplements and products:
This product is intended for adults. All use of dietary supplements should be done at your own risk and in consultation with a doctor, especially in the case of existing health problems or pregnancy. The recommended daily dose must not be exceeded. The effect of this product can vary from person to person, and it is important to remember that nutritional supplements cannot replace a varied diet. Keep out of the reach of children. Uno Vita AS does not claim that the products we market can cure, treat or prevent diseases.
General disclaimer:
Uno Vita AS increasingly uses artificial intelligence in analyses, summaries and development of content for product descriptions and articles. We are not responsible for possible errors or inaccuracies due to human or technological (including AI) errors. The information on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment. All information and materials provided are provided "as is" without warranties, either expressed or implied, including, but not limited to, implied warranties of merchantability or fitness for a particular purpose.
Freedom of expression and the right to share information:
Uno Vita AS reserves the right to share publicly available research and information on health and wellness technologies, natural substances and vitamins. This is done in accordance with national and international laws that ensure freedom of expression and belief, including:
-
The UN Universal Declaration of Human Rights (1948), Article 19, which ensures the right to freedom of opinion and expression.
-
The International Covenant on Civil and Political Rights (1966), Article 19, which emphasizes the right to freedom of expression.
-
Section 100 of the Norwegian Constitution, which ensures freedom of expression.
-
The United States' First Amendment, which protects freedom of speech.
