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Depression is more than a chemical imbalance: Talk therapy, biochemistry and a holistic root cause perspective

Jan Fredrik Poleszynski |

The article explains how depression can be affected by an interaction between:

  • Psychological patterns, brooding, trauma and life stress
  • Sleep, circadian rhythm and possible sleep apnea
  • Metabolism, anemia, iron status, B12, folate and vitamin D
  • Inflammatory signals and immunological processes
  • The gut–brain axis and the microbiome
  • Blood sugar, insulin resistance and metabolic health
  • Omega-3, magnesium and targeted nutritional support
  • Mitochondria, ATP and the membrane potential of nerve cells
  • Physical activity, daylight, diet and social support
  • Medicines, drugs and documented environmental exposure
  • Photobiomodulation, PEMF, rTMS and other neuromodulation

The new Norwegian psychotherapy study is presented precisely: the result is interesting, but the study only had 100 participants, and the treatment rule must be validated in independent datasets before it can be used as a clinical conclusion. The original study in PubMed and the review at forskning.no is included.

The article clearly distinguishes between:

  • Established clinical treatment
  • Documented supporting factors
  • Promising, but currently uncertain research areas
  • General wellness products and clinical transcranial protocols

This provides a balanced Uno Vita profile that is open to biochemistry and biophysics, but without exaggerating the documentation or promising treatment effect.

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