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Detoxification with Glutaryl - a comprehensive and safe approach

Jan Fredrik Poleszynski |

Introduction
Detoxification is a natural and continuous process that the body carries out through the liver, kidneys, intestines, skin and lungs. In today's society, we are exposed to an increasing burden from environmental toxins, heavy metals, pesticides, air pollution, medical residues, plastic chemicals and microplastics. Although the body has its own systems to deal with this, the amount and complexity of modern pollution can exceed the capacity of the natural detoxification apparatus. This can cause toxins to accumulate in tissues, and many people experience symptoms of overload. Support for the body's detoxification is not about doing something unnatural, but about helping the body carry out its natural processes in a more efficient way.

Glutathione's role in the body
Glutathione (GSH) is the body's most important intracellular antioxidant. It consists of three amino acids – glutamic acid, cysteine ​​and glycine – and is found in high concentrations in almost all cells. Glutathione has many important roles: it neutralizes free radicals, participates in the regeneration of vitamins C and E, is crucial in the liver's phase II detoxification, protects DNA, mitochondria and cell membranes from damage, and regulates the immune system. When glutathione binds toxins via glutathione-S-transferases, they can be safely transported out of the body through bile or urine. Without sufficient glutathione, the body can have problems eliminating environmental toxins, heavy metals and oxidative by-products.

Why Glutaryl
Traditional oral glutathione has low bioavailability because it is rapidly broken down in the gut. Liposomal formulations improve absorption but are dependent on digestion. Intravenous administration provides a rapid effect, but requires medical monitoring and is invasive. Glutaryl (Auro GSH™ transdermal spray) is an innovative alternative that makes it possible to supply glutathione directly through the skin. This bypasses digestion and provides a steady supply with high bioavailability. One spray corresponds to approx. 100 mg reduced glutathione. Due to the rapid and efficient absorption, it is necessary to start with a low dose and gradually increase to avoid the body mobilizing more toxins than it can excrete.

Why gradual escalation
When glutathione levels are rapidly increased, the liver and kidneys can begin to mobilize toxins at a rate that exceeds binding and excretion. This can cause temporary reactions such as dizziness, headache, upset stomach or fatigue. Clinical studies on glutathione supplementation and experience from detoxification clinics show that a gradual increase results in better tolerance. The principle "start low, go slow" is therefore both scientifically and clinically rooted. By starting with one spray every other day and gradually increasing to two sprays daily after 5-8 weeks, you give the body time to adapt and avoid discomfort.

🌍 Complete detoxification protocol

🟢 Step 1: Preparation (1–2 weeks)

The aim is to build a foundation so that the body can withstand increased detoxification.

  • 🚰 Hydration: drink 1.5–2 liters of water daily, preferably structured or hydrogen-rich. Add electrolytes such as ConcenTrace Mineral Drops.
  • 🌾 Bowel health: ensure daily bowel movements. Magnesium supplements can help. Fiber from vegetables, seeds and Uno Vita's products such as Chlorella and Spirulina contributes to the binding of toxins in the intestine. 
  • 🍊 Antioxidant support: start with vitamin C min 500 mg daily. Uno Vita offers Buffered Vitamin C Powder and Altrient Liposomal C and QS Lipsomal Vitamin C and more
  • 🔋 Micronutrients: zinc (PicoZinc Plus), selenium (SelenoExcel) and B vitamins support the enzymatic processes of detoxification.

🟡 Step 2: Introduction of Glutaryl (weeks 1–2)

Here you start carefully.

  • 💧 Dosage: 1 spray of Glutaryl every other day on clean skin.
  • 🛡️ Binder: start with ZeoBent MED® or Ultra Binder Sensitive with Pectin, once daily.
  • 🍊 Vitamin C: increase to at least 1000 mg daily.
  • 🚰 Hydration and electrolytes continue.
  • 🌿 Supplement with chlorophyll and broccoli extract to support liver detoxification enzymes.

🌿 When might it be right to start MCP immediately?

  • If the person already has good bowel function (1-2 bowel movements per day, plenty of fluid intake, no tendency to constipation).

  • If the person concerned has previously used binders and tolerates them well.

  • If there is a suspicion of a high circulating toxin load, where one wants to ensure rapid binding from the start.

  • If the detoxification program is run under guidance, where doses can be adjusted quickly in case of reactions.

👉 One can start with modified citrus pectin from day one, but it is often recommended to wait 1-2 weeks to give the body time to establish fluid balance, electrolyte support and bowel movement. This means that unnecessary reactions are avoided and the dosage can be adjusted more easily.

🟠 Step 3: Basic support (weeks 3–4)

Now you use Glutaryl daily and build further support.

  • 💧 Dosage: 1-2 sprays of Glutaryl every day (2 sprays if you do not experience detoxification reactions, see below).
  • 🌿 Liver Support: Liver Sauce – Super Detox or Silymarin Milk Thistle.
  • 🌱 Kidney support: Kindey Care.
  • 🛡️ Binders: 1–2 times daily.
  • 🍊 Vitamin C: at least 1000 mg daily.
  • ⚡ Add NAC as a precursor to glutathione.

🔴 Step 4: Therapeutic phase (weeks 5–8)

Here, mobilization is increased under controlled support.

  • 💧 Dosage: 2 sprays of Glutaryl daily (morning and evening).
  • 🛡️ Binders: ZeoBent MED®, Ultra Binder, modified citrus pectin.
  • 🌿 Liver and kidney support continues.
  • ⚡ Mitochondrial Support: Q10, NADH, Ribose contributes to energy stability.
  • 🧖 Light sweating via sauna or exercise supports the excretion of fat-soluble toxins such as PCBs and phthalates.

⚪ Step 5: Maintenance (from week 9 onwards)

Here, the use is stabilized to a level that suits your body.

  • 💧 Dosage: 1-2 sprays daily (or more) or 3-5 times a week.
  • 🛡️ Binders: can be used periodically.
  • 🌿 Continue vitamin C, selenium, zinc and liver/kidney support as needed.
  • 😴 Focus: sleep, rest and balanced diet.


🌟 Other supporting products from Uno Vita

  • ⬇️ Ultra Binder Sensitive with Pectin: broad-spectrum binder that binds heavy metals, mycotoxins and other toxins in the gut.

  • ⬇️ ZeoBent MED®: ultra-fine mixture of zeolite and bentonite that binds histamine and heavy metals.

  • ⬇️ Modified citrus pectin (MCP): binds heavy metals and prevents recirculation via bile.

  • 🌱 Chlorella and Spirulina: binds heavy metals, adds chlorophyll and supports intestinal flora.

  • 🌿 Broccoli extract: stimulates Nrf2 and the body's own detoxification enzymes.

  • 🍃 Chlorophyll: binds toxins and supports liver function.

  • 🌊 Fulvic acid: contributes to binding of heavy metals, mineral transport and electrolyte balance.

  • 💧 Hydrogen water and structured water: supports hydration, redox balance and the cells' detoxification capacity.

  • 🛡️ Liver Sauce® (Super Fees): liposomal mixture with silymarin, R-ALA, DIM and herbs that support all phases of detoxification.

  • 🌿 Silymarin (Milk Thistle): traditional herb that protects and supports liver function.

  • 🛡️ Liposomal Glutathione: direct supply of reduced glutathione with high bioavailability.

  • 🛡️ Glutathione Pro Liposomal capsules: convenient capsule variant of liposomal glutathione.

  • 🍊 Vitamin C: regenerates glutathione and protects cells against oxidative stress.

  • R-ALA (R-lipoic acid): powerful antioxidant that works synergistically with glutathione and supports mitochondrial function.

  • NAC (N-acetylcysteine): precursor to glutathione, increases the body's own production.

  • 🔋 Q10: supports the mitochondria's energy production.

  • 🔋 NADH: contributes to electron transport and energy turnover.

  • 🔋 Ribose: helps to build up ATP reserves in case of increased energy demand.

  • 🔋 Electrolytes: ensures fluid balance and supports the kidneys' ability to excrete toxins.


🔬 What one can experience during detoxification

  • 🧠 Dizziness: signs of mobilization, resolved with rest, vitamin C and hydration.
  • ⚡ Headache: supported with magnesium and fresh air.
  • 💧 Stomach: binders and fiber.
  • 🌿 Pressure on the kidneys: increase fluid intake and use renal support.
  • 😴 Fatigue: rest and mitochondrial support.

    These are normal signs that the body is working. Most reactions are transient. If you experience discomfort, it is usually because you are moving too quickly in relation to the body's ability to excrete waste and toxins.  You can always take a one-day break from the protocol.

📱 Digital detox

In addition to physical toxins, we are today exposed to a continuous digital load. Mobile phones, wireless networks and screens not only cause information stress, but also exposure to electromagnetic fields (EMF). This can increase oxidative stress, disrupt the redox system and thus affect the cells' electrical balance (transmembrane potential). When the redox environment shifts towards oxidation, the cells are depleted of electrons, the cell voltage drops and the mitochondria's energy production weakens.

📱 Mobile phone use and oxidative stress
🔬 Studies show that EMF from mobile phones (0.8-2.6 GHz, GSM, 3G, 4G, 5G) can:
• Increase the production of reactive oxygen species (ROS)
• Reduce intracellular glutathione (GSH)
• Alter antioxidant enzymes (SOD, catalase, glutathione peroxidase)
• Create an imbalance in the redox ratio (GSH/GSSG) – the key to the cells' redox status and stress level

🧬 The redox system maintains the balance between oxidation and reduction. An excess of electrons (reduction) makes the membrane more negative and the cell rich in energy. Loss of electrons (oxidation) causes depolarization and weaker cell voltage.

📑 Scientific basis
• A systematic review (Yakymenko et al., 2016) found that >90% of studies reported increased ROS or decreased antioxidant defenses upon EMF exposure
• In vitro: human blood cells exposed to 1800 MHz showed increased ROS and DNA damage
• Animal studies: rats had lower glutathione levels in the brain and liver when exposed to mobile radiation
• Human studies: some showed increased markers for oxidative stress (MDA) in long-term mobile phone users

⚖️ Conclusion
✅ Mobile phone use can contribute to increased oxidative stress and disturbed redox balance
✅ This affects cell voltage and mitochondrial energy
✅ The documentation is strongest in laboratory and animal studies, but is also found in humans
✅ The effect varies with exposure time, distance, signal type and individual sensitivity

🌿 Practical measures for digital detoxification
• 📴 Put your phone on airplane mode at night
• 🌙 Limit screen use in the evening to protect melatonin and sleep
• 🔌 Use wired internet whenever possible instead of wireless
• 🌳 Stay out in nature and walk barefoot (grounding)
• 🛡️ Support the redox balance with glutathione, vitamin C and R-ALA
• 🔴 Use red light/photobiomodulation to strengthen the mitochondrial membrane potential

⚖️ Disclaimer and reservations

Glutaryl and the other products are food supplements and not drugs and technologies that support the body's natural processes. They are not intended to treat, prevent or cure disease. People with serious liver or kidney disease, pregnant women or those who are breastfeeding should consult a healthcare professional. Binders can affect the absorption of medicines and should be taken separately.

📜 Freedom of expression and right to information

Uno Vita shares research and information on detoxification in line with the right to freedom of expression and the right to receive and disseminate information, anchored in the UN Declaration of Human Rights Article 19, Norwegian Constitution §100 and international conventions.

📚 References

  1. Richie JP Jr, et al. Randomized controlled trial of oral glutathione supplementation. Eur J Nutr. 2015.
  2. Allen J, Bradley RD. Effects of oral glutathione supplementation. J Altern Complement Med. 2011.
  3. Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992.
  4. Sekhar RV, et al. Glutathione synthesis in diabetes. Diabetes Care. 2011.
  5. Pizzorno J. Glutathione! Integr Med. 2014.
  6. Allen J, et al. Supraphysiological concentrations of reduced glutathione cause paradoxical oxidative stress. Free Radic Biol Med. 2014.
  7. Ballatori N, et al. Glutathione: a master antioxidant. Biochim Biophys Acta. 2009.
  8. Li C, et al. Pharmacokinetics of glutathione. Curr Drug Metab. 2018.
  9. Higashi T, et al. Clinical pharmacology of glutathione. Nihon Yakurigaku Zasshi. 2000.
  10. Nance EA, et al. Glutathione in neurological disorders. Nutr Neurosci. 2012.
  11. Dröge W. Glutathione and immune function. Proc Nutr Soc. 1999.
  12. Townsend DM, et al. The importance of glutathione in human disease. Biomed Pharmacother. 2003.
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