Akkermansia muciniphila (pasteurized) – 30 billion cells per capsule

Akkermansia muciniphila capsules are an advanced postbiotic dietary supplement developed to support the intestinal flora, microbiome and intestinal barrier. Akkermansia muciniphila is a natural bacterium in the intestinal mucus layer and is among the most studied microorganisms in modern microbiome research. This product uses pasteurized Akkermansia muciniphila, where the bacteria's bioactive cell membranes and proteins are preserved after heat treatment. This postbiotic approach provides stability at room temperature and makes the product compatible with probiotics and other microbiome supplements. Each capsule contains 30 billion bacterial cells and represents a next-generation microbiome strategy for people who want advanced support for gut health, microbiota and digestive balance.

Akkermansia muciniphila is a naturally occurring bacterium in the human intestinal flora that lives in the mucus layer of the intestine. This dietary supplement contains 30 billion pasteurized Akkermansia muciniphila cells per capsule (3×10¹⁰ TFU). Pasteurization preserves the bacteria's cell membrane and bioactive structures, including membrane proteins such as Amuc_1100, which can interact with receptors in the intestinal wall even after heat treatment. The pasteurized form therefore functions as a so-called postbiotic – bioactive bacterial components without living microorganisms – and is stable at room temperature without the need for refrigeration. The product is produced in the Netherlands in an FSSC 22000-certified production facility and is supplied in vegetable capsules without gluten, lactose or artificial additives.

Health benefits
• Can help support a balanced composition of the intestinal microbiota as part of a varied diet
• Can help support normal function in the intestinal mucus barrier through bioactive cell membrane proteins
• Can contribute to favorable communication between intestinal bacterial components and immune cells in the intestinal mucosa
• Can help support normal metabolic regulation through interaction between intestinal flora and the host's metabolism
• Can be combined with probiotics without competition between live bacterial strains
• Stable at room temperature and suitable for daily use without the need for refrigeration
• Represents a new generation of postbiotic supplements where the effect is primarily linked to the bacteria's structure rather than viability

Technical details and specifications
Contents: 30 capsules
Active content: 30 billion pasteurized Akkermansia muciniphila cells per capsule (3×10¹⁰ TFU)
Raw material: Akkermansia muciniphila 3×10¹¹ TFU/g
Capsule type: Vegetable HPMC
Production: FSSC 22000-certified production in the Netherlands
Quality control: Tested for identity, cell concentration, microbiological purity, heavy metals and pathogens (E. coli, Salmonella, Listeria)
Stability: Room temperature, no refrigeration required
Free from: Gluten, lactose, yeast, artificial colours, flavors and preservatives
GMO-free and not irradiated according to EU regulations

Label information
Ingredients: Akkermansia muciniphila (pasteurized), microcrystalline cellulose (filler), hydroxypropyl methylcellulose (vegetable capsule).
Recommended use: 1 capsule daily or as recommended by a qualified healthcare professional.
Storage: Dry and cool, inaccessible to children.

Reservation
Food supplements should not be used as a substitute for a varied diet and a healthy lifestyle. Pregnant, breastfeeding women and people who use medication or have an illness should consult a doctor before use.

Disclaimer
The product is a dietary supplement and is not intended to diagnose, treat, cure or prevent disease.

Freedom of expression
The information is provided for nutritional and scientific guidance in accordance with principles of freedom of expression and current regulations.

Scientific references

1. Derrien M et al. Akkermansia muciniphila gen. Nov. Int J Syst Evol Microbiol. 2004.

2. Cani PD, de Vos WM. Next-generation beneficial microbes: The case of Akkermansia muciniphila. Front Microbiol. 2017.

3. Depommier C et al. Supplementation with Akkermansia muciniphila in overweight humans. Nat Med. 2019.

4. Plovier H et al. A purified membrane protein from Akkermansia muciniphila improves metabolism. Nat Med. 2017.

5. Everard A et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium. PNAS. 2013.

6. Cani PD et al. Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nat Rev Gastroenterol Hepatol. 2022.

7. Schneeberger M et al. Akkermansia muciniphila improves gut barrier function. Gut. 2015.

8. Dao MC et al. Akkermansia muciniphila and metabolic health. Gut. 2016.

9. Chelakkot C et al. Akkermansia muciniphila-derived extracellular vesicles. Exp Mol Med. 2018.

10. Ottman N et al. Pili-like proteins of Akkermansia muciniphila. Appl Environ Microbiol. 2017.

11. Zhang T et al. Akkermansia muciniphila and intestinal barrier integrity. Front Immunol. 2019.

12. Belzer C, de Vos WM. Microbes inside—from diversity to function. Nat Rev Microbiol. 2012.

13. Zhou Q et al. Gut microbiota modulation by Akkermansia muciniphila. Nutrients. 2021.

14. Xu X et al. Akkermansia muciniphila in metabolic disorders. Int J Mol Sci. 2020.

15. Bian X et al. Microbiota-host interactions in mucosal immunity. Trends Immunol. 2022.

16. Wang L et al. Gut microbiota and metabolic regulation. Microbiome. 2020.

17. Derrien M, Belzer C. Akkermansia muciniphila and its role in the gut ecosystem. Microb Pathog. 2017.

18. Everard A, Cani PD. Gut microbiota and metabolic diseases. Best Pract Res Clin Gastroenterol. 2013.

19. de Vos WM. Microbial interactions with the human host. Nat Rev Microbiol. 2022.

20. Cani PD. Human gut microbiome: therapeutic potential. Nat Rev Gastroenterol Hepatol. 2018.

21. Depommier C et al. Pasteurized Akkermansia muciniphila clinical safety study. Nat Med. 2019.

Tags