ADVANCED Active Hexose Correlated Compound Fucoidan Formula

Summary
ADVANCED Active Hexose Correlated Compound Fucoidan Formula is an advanced, vegan dietary supplement that combines selected mushroom extracts rich in alpha and beta glucans with premium Maritech® fucoidan from brown algae. The raw materials are selected with a focus on high purity, documented quality, traceability and consistent content. The product is formulated without fillers, binders or unnecessary additives, and the capsules are made from pullulan from tapioca. The packaging is environmentally friendly and recyclable.

Health benefits
• 🛡️ alpha- and beta-glucans from medicinal mushrooms have been studied for their role in the body's normal immune-related processes
• 🔬 AHCC has been investigated in research as a fermented mushroom-based complex rich in low molecular weight alpha-glucans
• 🌿 fucoidan from brown algae has been studied for properties related to cell interactions, antioxidative mechanisms and general nutritional support
• ⚖️ the combination of mushroom glucans and fucoidan has been explored in some studies for possible interaction in the body's normal response mechanisms
• 🔁 suitable for daily use as part of a long-term diet and lifestyle regime

The effects described in the literature are linked to normal physiology and ongoing research, and may vary between individuals.

Technical details / specifications
• Form: vegan capsules of pullulan (from tapioca)
• Without fillers, binders or artificial additives
• Manufactured in the UK to GMP standards
• Packaging: recyclable bag
• Fucoidan raw material: Maritech® (Marinova, Australia)
• Mushroom-based raw materials: selected suppliers with specialized expertise

Label information
Statutory designation: dietary supplement

Ingredients per capsule:
• 300 mg shiitake-based Active Hexose Correlated Compound (AHCC)
• 150 mg "Mixed AHCC" (shiitake, reishi, maitake, royal sun and chaga)
• 85 mg maitake extract (Grifola frondosa) standardized to 50% polysaccharides and 30% beta-1,3/1,6-D-glucan
• 50 mg shiitake extract (Lentinula edodes) standardized to 50% polysaccharides and 30% beta-1,3/1,6-D-glucan
• 20 mg Maritech® wakame extract standardized to 85% fucoidan
• Capsule: pullulan (tapioca)

Recommended daily dose:
1–2 capsules daily, approx. 30 minutes before food. In case of increased need, the intake can be divided in the morning and evening. Up to 4 capsules daily by agreement with healthcare personnel.

Reference intake (RI): not established.

Allergens: no declarable allergens added.

Storage: dry and cool below 25 °C, tightly closed and inaccessible to children. Do not use if the seal is broken.

Manufacturer: GMP certified manufacturer in the UK
Importer/responsible business in the EEA: Uno Vita AS, Moss, Norway
Batch/Lot and best before: stated on the packaging

Reservation
Allowed to be used by adults. The recommended daily dose should not be exceeded. The effect may vary from person to person. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Keep out of the reach of children.

Disclaimer
This product is a dietary supplement and is not intended to diagnose, treat, cure or prevent disease. The information is provided as general consumer information.

Freedom of expression
The information is based on publicly available research and specialist literature and is shared in line with freedom of expression, Section 100 of the Constitution, Article 19 of the UN Universal Declaration of Human Rights and applicable Norwegian and European regulations.

Scientific references

1. Smith JA et al. AHCC® supplementation to support immune function. Frontiers in Oncology, 2022.

2. Smith JA et al. From bench to bedside: evaluation of AHCC®. Frontiers in Oncology, 2019.

3. Gao Y et al. Active Hexose Correlated Compound enhances immune responses. Cancer Immunol Immunother, 2006.

4. Volman JJ et al. Dietary modulation of immune function by β-glucans. Crit Rev Food Sci Nutr, 2008.

5. Chan GC et al. Polysaccharide-protein complexes from medicinal mushrooms. Appl Microbiol Biotechnol, 2009.

6. Vetvicka V, Vetvickova J. β-Glucan effects on immune reactions. Open Biochem J, 2012.

7. Ale MT et al. Fucoidans from brown seaweeds. Mar. Drugs, 2011.

8. Fitton JH. Therapies from fucoidan. Mar. Drugs, 2011.

9. Fitton JH et al. The pharmacology of fucoidan. Mar. Drugs, 2015.

10. Li B et al. Structure-function relationship of fucoidan. Carbohydr Polym, 2008.

11. Shimizu J et al. Maitake D-fraction and immune parameters. J Med Food, 2002.

12. Wasser SP. Medicinal mushrooms and polysaccharides. Appl Microbiol Biotechnol, 2002.

13. Ooi VE, Liu F. Mushroom polysaccharide-protein complexes. J Ethnopharmacol, 2000.

14. Brown GD, Gordon S. Immune recognition of fungal β-glucans. Cell Microbiol, 2005.

15. Ikeda Y et al. Characterization of fucoidan fractions. Int J Biol Macromol, 2001.

16. Berteau O, Mulloy B. Sulfated fucans. Glycobiology, 2003.

17. Klebanov GI et al. Antioxidant properties of mushroom polysaccharides. Int J Med Mushrooms, 2019.

18. Jayachandran M et al. Health-promoting effects of mushroom polysaccharides. Trends Food Sci Technol, 2017.

19. Tzianabo's AO. Polysaccharide immunomodulators. Clin Microbiol Rev, 2000.

20. Fitton JH et al. Fucoidan developments. March Drugs, 2019.

21. Ikegami S et al. Pullulan as a food ingredient. Food Sci Nutr, 2018.