Frequently Asked Questions
What is deuterium and Preventa deuterium-depleted drinking water?
Deuterium, a.k.a. heavy hydrogen, is a naturally occurring stable – non-radioactive – variation of hydrogen. The atomic nucleus of hydrogen consists of one proton only, but the deuterium nucleus contains one proton and one neutron. This considerable, twofold mass difference causes significant differences in the physical and chemical properties of hydrogen and deuterium. Preventa, the world’s first drinking water product family with lowered deuterium content, was developed on the basis of an international patent by HYD LLC. Preventa drinking water was licensed by the Budapest Veterinary Health and Food Control Station in 1999, based on expert opinion of Fodor József National Centre of Public Health, Institute of Environmental Health, and National Institute for Food and Nutrition Science.

Why should we drink Preventa deuterium-depleted water?
Research shows that decreasing the level of deuterium in the tissues and organs is a natural biological process. However, the body's ability to deplete deuterium decreases as we get older, sicker and get less exercise or sunlight. This natural system is the target of the deuterium depleting procedure. By changing the deuterium level of drinking water below the natural level, the deuterium content in the body can be kept low even if the said natural cell process is faulty. By proper choice and continuous consumption, deuterium depletion in the organism can be maintained for long periods.

What is the recommended daily amount of deuterium-depleted water?
It is possible to cover the daily water intake (1.5-2 liters a day for an adult of average body weight) with deuterium-depleted water, which can be consumed as such but can also be flavored or used for cooking or making tea or coffee. It is important that intake of fluid with normal deuterium level (tap water, mineral waters, soft drinks, fruit juices, milk) should be minimized.

Which Preventa water should one choose?
The lower is the deuterium content of a given Preventa water, the farther it is from that of the natural waters which is 140-145 ppm in our climatic zone. By proper choice and continuous consumption, deuterium depletion in the organism can be maintained for long periods.

How to lower the deuterium content of the body?
The easiest way to influence the deuterium content of our body is to decrease the deuterium concentration of drinking water. By consuming drinking water with lower than natural deuterium concentration, deuterium content in our organism will be decreased because the organism’s normal water content will mix with the deuterium-depleted water.

This can be complemented by other deuterium-depleted foods – e.g., a deuterium-depleted mushroom extract – because their organic molecules are also low in deuterium. Supplemental consumption of plants grown under deuterium-depleted conditions, or foods made from the former, can contribute to more efficient lowering of deuterium content in the body. Deuterium-depleted foodstuffs represent a novel product category, the characteristic property of which is, in analogy to cholesterol-free or low carbohydrate foods, the low deuterium content.

What are the specialities of Preventa deuterium-depleted drinking waters? – How deuterium content is determined?
The deuterium content of Preventa drinking waters is by far lower than the natural value, and the degree of depletion is higher than the natural variation of deuterium level. The deuterium content of water is normally given in ppm (parts per million) units, which shows, how many in one million hydrogen atoms are deuterium, or how many in one million water (H2O) molecules are heavy water (D2O). Deuterium content can be measured by mass spectrometry and laser-based techniques.

What is the meaning of numbers indicated on Preventa deuterium-depleted products?
The numbers indicated in the names of Preventa drinking waters mean the deuterium content of that product in ppm units. Accordingly, Preventa 125 contains 125 ppm, Preventa 105 contains 105 ppm, and Preventa 85 contains 85 ppm deuterium, in contrast to the 140-145 ppm typical for surface waters – and hence, for ordinary tap water – in our geographical zone.

Carbonated or non-carbonated?
Mineral waters and drinking waters are available in carbonated and non-carbonated form. It is important to know that the two variations have approximately the same mineral content, therefore there is no significant difference between them as regards acid-base balance in the organism. Added carbon dioxide contributes to the long-term stability of the quality of waters.

What is the natural global variations of the deuterium content of precipitation? – About the deuterium content of the human body
The deuterium content of living organisms is determined primarily by the deuterium level of oceanic water and of precipitation arriving at the ground. Deuterium level in precipitation decreases from the Equator to the North and South Pole, from the oceans into the continents, and in proportion with increasing elevation. In our climatic zone, deuterium content of the surface waters is 140-150 ppm with little variability. The human body consists prevailingly of water, but the proportion of water decreases with age. Considering that ca. 60% of our body is water, and that organic compounds also contain deuterium, the concentration of deuterium in the human organism is severalfold higher than the normal level of other physiologically important elements such as calcium, potassium or magnesium.

What is the method of reducing deuterium level in water?
Deuterium-depleted water is produced by an energy-demanding technology based on differences in the physicochemical properties of normal water (H2O) and heavy water (D2O). Due to a boiling point difference of merely 1.5°C, the concentration of heavy water (with higher boiling point) is lower in the vapour phase and this fact is utilized for producing deuterium-depleted water. By repeating evaporation several times in so-called distillation columns, the deuterium content of water can be reduced to any level.

Is there a way to produce home-made deuterium-depleted water?
By means of home distillers, not more than 1 ppm decrease can be achieved by single, or 2-3 ppm by double distillation, and this is insignificantly little change in the deuterium concentration of water. Substantial decrease of deuterium content in water can be achieved only by an industrial scale technology, fractional distillation. Preventa products contain 15 to 84% less deuterium than our natural waters, whereas home distillers alter the deuterium content of water by a mere 1-1.5%.

HYD LLC. for Cancer Research and Drug Development was established in 1993 for the development and worldwide marketing of drugs and consumer products primarily for the prevention and treatment of various kinds of cancer, that utilize a novel proprietary procedure, deuterium depletion. Deuterium depletion is a completely original approach to inhibit the growth of cancer cells in the body and to influence other physiological processes offering a completely safe, non-invasive at the same time a highly effective treatment modality.

All research and development, including drug registration and other product development, based on deuterium depletion technology is exclusively managed, organised and financed by HYD LLC. Different applications of deuterium depletion are protected by international patents and patent applications in most of the developed countries.

In recent years HYD entered the international market, the professional reputation and international recognition of the patent-protected deuterium depletion technology continues to grow. Research has started in several foreign countries in academic institutions, universities and cancer centers.

The milestones of HYD’s history, and its major achievements, prizes and acknowledgements, are as follows:

• 1995 – HYD LLC started its first human phase II clinical investigation on patients with prostate cancer.
• 1996 – The patent of HYD won a price at the patent exhibition Genius ’96.
• 1998 – The patent of HYD won a price at the patent exhibition Genius First Inventors’ Olympic Games.
• 1999 – HYD LLC. completed the development and registration of its new veterinary drug, Vetera-DDW-25® A.U.V., for the treatment of households pets with tumors.
• 2000 – The new formulation of deuterium-depleted drinking water protected by the international Preventa® trademarks was placed on the market.
• 2002 – HYD LLC was rewarded as the 9th fastest developing company of the Central and East European Region in the competition announced by Deloitte & Touche international auditor company. In the region comprising Europe, Middle East and Africa, HYD had the 40th place. The price was delivered to the leaders of the first 500 companies in November 2002 in London.
• 2003 – HYD LLC had the opportunity to introduce itself on EuroNews TV, the program was broadcast in five languages.
• 2005 – Preventa® deuterium-depleted drinking water, developed by HYD, won the first prize at the international innovation contest “New Foods”. The jury especially emphasized the importance of the research and the products based on deuterium-depleted water in health preservation.
• 2009 – In October 2009, HYD LLC opened its first store in Budapest. Beyond selling Preventa® product family, the place was home of high-level professional events.
• 2010 – HYD organized the First International Symposium on Deuterium Depletion in Budapest. Leading scientists of four countries (Hungary, USA, Russia, Iran) presented their results on research and various applications of deuterium depletion. The aim of the two-day symposium was to present the results of research on deuterium depletion, and to determine the present and future place and role of the procedure in anticancer research and therapy, and in research on diabetes and aging.
• 2011 – HYD LLC opened its second store in BAH Center Office Building in Budapest.
• 2012 – At the Second International Congress on Deuterium Depletion, organized by HYD, scientists of seven countries (USA, France, China, Russia, Turkey, Romania, Hungary) presented their results on research and practical application of deuterium depletion.
• 2012 – Primus Capital closed a HUF 400 Million HUF investment in HYD Pharma Ltd. The investment is being used for validation of research results, and for implementation of a new human phase II clinical test.
• 2014 – The Preventa brand and product design was renewed, the new product line and the latest packaging materials met the highest consumer expectations. The product line has been marketed in a unique bottle with self-adhesive foil label, and the distinction between different deuterium-based Preventa products was enhanced by the unique color coding features of the product family.
• 2015 – The 3rd International Congress on Deuterium Depletion was held in May 2015 in Budapest, Hungary. At the conference leading scientists from seven countries (USA, France, Spain, United Kingdom, Russia, Sweden, Hungary) presented and discussed current advances in the research and various application of deuterium depletion.Following a successful audition by the Hungarian National Institute of Pharmacy and Nutrition in May, 2015, Trigon Biotechnology Inc., strategic partner of the mother company of HYD LLC, HYD Pharma Inc., has received new GMP compliance certificates for the deuterium-depleted water (DDW) producing facility of HYD Pharma. DDW as Active Pharmaceutical Ingredient was also registered at the European Medicine Agency (EMA) and an EudraCT number 2015-003820-30 was issued for the Protocol Code Number HYD-HD85/45-CLL-02.
  
• 2016 – HYD Pharma Inc. was granted ethical approval by the State Institute for Drug Control (SIDC) in Slovakia for Phase 2 as one-of-the-first clinical trials to prove the anticancer effect of deuterium-depleted water (DDW) in chronic lymphocytic leukemia (CLL).
• In 2016, Preventa® deuterium-depleted drinking water product line was awarded with the MagyarBrands honorable award in the Outstanding Consumer Brand category.
• 2019 – The 4th International Congress on Deuterium Depletion took place between 17-18 October 2019, in Budapest. The two-day conference aimed at presenting the newest research outcomes and clinical applications of deuterium depletion, and determining the present and future role of the process in antitumor research and prevention, as well as in the treatment of other, primarily metabolic, diseases, and in the research of aging.The conference provided a broad scientific forum for domestic and foreign researchers and doctors in this field to share their latest results. By bringing the leading scientists of deuterium depletion of the world together, the conference was, beyond science, also a forum for establishing connections and collaborations.
• 2020 – The first deuterium-depleted dietary supplement was put in circulation. Preventa deuterium-depleted oyster mushroom extract is the only 100% natural product of oyster mushrooms that is produced in cultivation using water with reduced deuterium content of 85 ppm. Directorate of Veterinary Products of the National Food Chain Safety Agency gave permission for the clinical investigation of Vetera-DDW-25 A.U.V. injection formula in dogs with breast tumors.

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