AMe – S-adenosyl-methionine 400 mg – 60 enteric-coated, vegetable tablets
Dietary supplement with S-adenosyl-methionine (SAMe) to support methylation, normal choline/phospholipid turnover and the body's own antioxidant defenses

SAMe (S-adenosyl-methionine) is the body's universal methyl donor and participates in hundreds of biochemical processes linked to signaling substances, phospholipids in cell membranes and formation of the body's own antioxidants (e.g. via sulfur transfer in glutathione synthesis). Each tablet contains 400 mg of SAMe in an enteric-coated, vegetable formulation that contributes to stability through the stomach and release in the intestine. The product is non-GMO.

Health benefits
SAMe is a naturally occurring substance in the body that is involved in, among other things, methylation, polyamine synthesis and transsulfuration pathways. Balanced information from research and professional resources indicates that SAMe can:
• Support the body's methylation processes (donates methyl groups in a number of reactions)
• Contribute to normal cell membrane structure through the influence of phosphatidylcholine/choline pathways
• Support the body's own antioxidant defenses via sulfur transfer in the synthesis of glutathione
• Support normal turnover of signaling substances (neurotransmitters) through methyl-related steps
• Contribute to general well-being by supporting physiological processes in the liver, joints and nervous system through nutritional physiological mechanisms (without medical claims)

Top 2 main features

1. Methylation support throughout the body
   SAMe is a central methyl donor and can support a wide range of enzymatic reactions that require methyl groups (for example in the turnover of phospholipids and certain signaling molecules).

2. Support for the body's endogenous antioxidant defences
   Via transsulfuration pathways, SAMe can contribute sulfur components that the body uses in the production of glutathione – one of the body's most important antioxidant systems.

A surprising or lesser known effect
SAMe is included in polyamine synthesis, which is relevant for normal cell growth and maturation. This biochemical role is less known outside the professional environment, but illustrates that SAMe has functions that go beyond pure methylation.

Technical details and specifications
• Content per tablet (daily dose): S-adenosyl-methionine (SAMe) 400 mg
• Enteric coating (designed for release in the gut)
• Vegetable tablets (non-GMO)
Other ingredients: Cellulose, methacrylic acid copolymer (enteric coating), mannitol, citric acid, stearic acid, silica, hypromellose, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, calcium carbonate, yellow ocher.
Free for: GMOs and gluten.
Form: Enteric-coated, vegetable tablets.
Origin/class: Food/dietary supplements.

Recommended use (Norway/EU – general)
Adults: 1 tablet daily, preferably on an empty stomach or as recommended by healthcare professionals. Higher intakes than 1 tablet per day should only be considered in consultation with qualified healthcare personnel.
Practical tip: The body uses B vitamins (B12, B6 and folate) as cofactors in methyl-related processes. A balanced diet covering the Reference Intake (RI) of these vitamins may be appropriate.

Label information
Dietary supplement: S-adenosyl-methionine (SAMe).
Recommended daily dose: 1 tablet.
Number of tablets per pack: 60 (60 days consumption at 1 tablet daily).
Storage: Dry, dark and inaccessible to children. Close the lid tightly.
Warnings: People with diagnosed bipolar disorder should not use SAMe. Consult a doctor before use if you are pregnant/nursing, taking medication (especially antidepressants/MAO inhibitors/SSRI/SNRI), have bleeding disorders or another medical condition.
Manufacturer: Life Extension (USA).
Importer and distributor: Uno Vita AS, Norway.

Reservation
Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person. Dietary supplements should not replace a varied diet. Should be kept out of the reach of children. Uno Vita AS does not claim that the products we market can cure disease.

Disclaimer
Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles. We do not accept responsibility for possible errors in texts, articles or descriptions due to human or computer technology (AI) errors, inaccuracies or missing information in scientific and medical studies. We encourage all readers to examine all information critically to ensure that the content is correct. Uno Vita does not claim medical effects of the products we sell, but we refer to publicly available research in accordance with the right to freedom of expression. The information is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment. The content must not be used as a basis for making diagnoses or choosing forms of treatment. Uno Vita disclaims all responsibility for loss or damage that may arise as a result of the use of information or products. Always consult a qualified healthcare professional before starting a new treatment, changing your diet or using supplements. Any use is at your own risk.

Freedom of expression and right to information
Uno Vita reserves the right to share publicly available research and information on health and wellness technologies and natural substances in line with the UN Universal Declaration of Human Rights art. 19, ICCPR art. 19, the Constitution §100 and the United States' First Amendment.

Scientific references

1. Mato JM, Lu SC. "Role of S-adenosyl-L-methionine in liver health and disease." Hepatology.

2. Bottiglieri T. “S-Adenosyl-L-methionine (SAMe): From the bench to the bedside – methylation, neurobiology, and clinical applications.” J Clin Psychiatry.

3. Watanabe F et al. "Methylation reactions in neurotransmitter metabolism." Clin Chem Lab Med.

4. Mischoulon D, Fava M. “Role of S-adenosyl-L-methionine in depression: a review of clinical studies.” Am J Clin Nutr.

5. Papakostas GI et al. "SAMe augmentation in major depressive disorder: randomized trial." Am J Psychiatry.

6. Najm WI et al. "S-adenosyl-L-methionine for osteoarthritic symptoms: evidence review." Fam Pract.

7. Kim H et al. "SAMe in osteoarthritis: meta-analysis of randomized trials." BMC Musculoskeletal Disord.

8. Anstee QM, Day CP. "S-adenosyl-L-methionine in liver disorders." Expert Opin Pharmacother.

9. Stramentinoli G. “Pharmacokinetics and bioavailability of SAMe.” Drugs Exp Clin Res.

10. De Berardis D et al. "SAMe in psychiatric conditions: mechanisms and evidence." CNS Neurol Disord Drug Targets.

11. Selhub J. "Methylation pathways, homocysteine and B-vitamins: biochemical interplay." Annu Rev Nutr.

12. Seppälä I et al. "Transsulfuration and glutathione synthesis: nutritional regulation." Nutr Metab.

13. Mudd SH et al. "Methionine metabolism and related disorders." Annu Rev Biochem.

14. Infante M et al. "Phosphatidylcholine synthesis and membrane dynamics." Nutrients.

15. Benedetti MS et al. "Enteric-coated SAMe: ​​stability and absorption." Int J Pharm.

16. Agency for Healthcare Research and Quality (AHRQ). "Evidence Report on SAMe for depression, osteoarthritis, and liver disease."

17. NCCIH. "S-adenosyl-L-methionine (SAMe): in-depth overview."

18. The Norwegian Food Safety Authority/VKM. "Risk assessment of S-adenosyl-methionine in dietary supplements."

19. EU Commission. "Classification of SAMe in food supplements (CN 2106 90 92)."

20. Mayo Clinic. "SAMe: ​​safety, interactions and use."

21. Yap S-P et al. "Bioavailability of SAMe: ​​formulation factors and food effects." Am J Clin Nutr.