Shitake Betaglucan, 50 ml

Shitake Betaglucan is a liquid dietary supplement containing Lentinex®, a patented and natural β-(1,3/1,6)-glucan extracted from the mycelium of shiitake mushrooms (Lentinula edodes) through a proprietary fermentation process. This process preserves the glucan's three-dimensional triple helix structure, which provides high bioactivity and efficiency. The product has been developed in Norway with over 20 years of research and has a higher β-glucan concentration than standard Lentinex®. It is free from preservatives, pesticides, solvents and heavy metals. Shitake Betaglucan supports the immune system, protects against oxidative stress and promotes intestinal health. With a daily dose of 1-2 ml, it is a pure, sustainable supplement for those who want to strengthen the body's natural defences.

Health benefits
Shitake Betaglukan contains β-(1,3/1,6)-glucan, also known as lentinan, with documented health effects supported by scientific research and in line with approved health claims from the European Food Safety Authority (EFSA). The product supports the body's natural processes without promoting medical claims about the treatment or prevention of diseases. The main benefits include:

• Support for the immune system: β-glucan contributes to the normal function of the immune system by activating immune cells such as macrophages, natural killer cells (NK cells) and T cells, which strengthen the body's defense against pathogens.

• Antioxidant protection: Protects cells against oxidative stress by neutralizing free radicals, which contributes to healthy cell function.

• Gut health: Promotes a healthy intestinal flora by supporting the balance of the intestinal microbiota and the normal functions of the digestive system.

• Anti-inflammatory support: May help maintain normal inflammatory responses, important for overall health and well-being.

• Energy and vitality: May indirectly increase feelings of energy and well-being by supporting the immune system and protecting cells.

• Cognitive support: Some studies suggest that β-glucan may have an indirect positive effect on cognitive function by supporting general cellular health, although this is not an approved health claim.

Important health effects and surprising benefits
The two most documented health effects of Shitake Betaglucan are support for the immune system and antioxidant protection. β-glucan activates immune cells such as NK cells and macrophages, which strengthens the body's ability to respond to pathogens. At the same time, it protects the cells against oxidative stress, which is essential for maintaining healthy cell function over time. A lesser-known benefit is β-glucan's potential role in supporting gut health by promoting the growth of beneficial gut bacteria, which may have positive effects on digestion and overall well-being, particularly in light of research on the gut-brain axis.

Technical details and grant facts
Shitake Betaglucan is produced with a focus on purity, quality and sustainability. Here are the technical specifications:

• Ingredients: Water, glucose, β-(1,3/1,6)-glucan (0.85–1.15 mg/ml triple helix betaglucan), protein (0.01%).

• Nutritional content per daily dose (1–2 ml):

  • β-glucan: 0.85–2.3 mg

  • Residual glucose: <20 mg/ml

  • Total protein: <0.05 mg/ml

• Recommended dosage: 1–2 ml daily, taken directly or mixed in water or food. In case of active disease, up to 1 ml can be taken every 4 hours, in consultation with a doctor.

• Packaging: 50 ml bottle, enough for 25-50 days of use at standard dosage.

• Appearance: Light brown liquid, slightly sour taste, odorless.

• Solubility: Completely soluble in water-based liquids.

• pH: 3–4.

• Specific gravity: 0,95–1,05.

• Microbial analysis: Total plate count <100 cfu/g, yeast/fungi <100 cfu/g, absence of pesticides, heavy metals and solvents.

• Storage: Store at 4–35 °C, do not freeze. Store dry, closed and out of the reach of children.

• Durability: 24 months in unopened packaging under recommended storage conditions.

• Certifications: Manufactured according to Good Manufacturing Practice (GMP) standards and DSHEA. GRAS-approved and Novel Food Approval.

• Sustainability: Produced by sustainable fermentation of shiitake mycelium, without the use of chemicals or additives.

Reservation
Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person. Dietary supplements should not replace a varied diet. Not recommended for children under 3, pregnant or breastfeeding. Should be kept out of the reach of children. Uno Vita AS does not claim that the products we market can cure disease.

Disclaimer
Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles. We do not accept responsibility for possible errors in texts, articles or descriptions due to human or computer technology (AI) errors, inaccuracies or missing information in scientific and medical studies. We encourage all readers to examine all information critically to ensure that the content is correct. Uno Vita does not claim medical effects of the products we sell, but we refer to publicly available research in accordance with the right to freedom of expression. The information on this website is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. The content must not be used as a basis for making diagnoses or choosing forms of treatment. All information and materials on this website are provided "as is" without any warranties, either expressed or implied, including, but not limited to, implied warranties of merchantability, fitness for a particular purpose or non-infringement. Uno Vita disclaims all responsibility for loss or damage that may arise as a result of the use of information or products from this website. We strongly recommend that you consult a qualified healthcare professional before starting any new treatment, dietary change or use of supplements. Any use of products or information from this website is at your own risk.

Freedom of expression and right to information
Uno Vita reserves the right to share publicly available research and information on health and wellness technologies, natural substances, vitamins and the like. We do this with reference to national and international laws on freedom of expression and belief, including:

• UN Universal Declaration of Human Rights (1948): Article 19 ensures the right to freedom of opinion and expression, including the freedom to receive and impart information without regard to borders.

• The International Covenant on Civil and Political Rights (1966): Article 19 emphasizes the right to freedom of expression and the freedom to seek, receive and communicate information and ideas through various media.

• Norwegian Constitution § 100: Ensures freedom of expression, with certain limitations for the sake of children's protection, privacy, public order and safety.

• America's First Amendment: Protects freedom of speech against government interference, and provides one of the strongest protections for free speech.

Uno Vita reserves the right to freedom of opinion and expression in line with these principles.

Scientific references

1. Immunomodulatory Effect and Biological Significance of β-Glucans. Pharmaceuticals (Basel). 2023.

2. Stimulatory Effect of β-glucans on Immune Cells. Biomolecules. 2022.

3. Immunomodulatory β-Glucan from Lentinus edodes Activates Mitogen-Activated Protein Kinases. Int J Mol Sci. 2021.

4. Safety and Efficacy of a Proprietary Undenatured Beta-Glucan on Immune Function. J Clin Trials. 2020.

5. Lentinan has a stimulatory effect on innate and adaptive immunity. Anticancer Agents With Chem. 2013.

6. β-Glucans: A Potential Source for Maintaining Gut Health. Front Nutr. 2022.

7. Lentinan from Shiitake Selectively Attenuates AIM2 and Non-Canonical Inflammasome Activation. Sci Rep. 2019.

8. The Effects of β-Glucan on Human Immune and Cancer Cells. J Hematol Oncol. 2009.

9. β-Glucan Extracts from the Same Edible Shiitake Mushroom Lentinus edodes Produce Differential In-Vitro Immunomodulatory and Pulmonary Cytoprotective Effects. Int J Mol Sci. 2020.

10. β-Glucan Vaccine Adjuvant Approach for Cancer Treatment. Int J Oncol. 2018.

11. Immunomodulatory Properties of Polysaccharides from Lentinula edodes. J Fungi (Basel). 2024.

12. Recent Research on the Use of Beta-Glucans in CVD and Immune Health. Today's Dietitian. 2023.

13. β‐1,3/1,6‐Glucans and Immunity: State of the Art and Future Directions. Mol Nutr Food Res. 2021.

14. β-Glucan Reduces Cortisol Plasma Levels, Enhances Innate Immune Response. Food Chem. 2021.

15. Anti-Tumor Effect of β-Glucan from Lentinus edodes and the Underlying Mechanism. Sci Rep. 2016.

16. CLEC7A and Its Role in β-Glucan Recognition. Front Immunol. 2020.

17. Lentinan: Structure, Bioactivity, and Applications. Wikipedia. 2024.

18. Beta-Glucan: Overview and Health Benefits. Wikipedia. 2024.

19. Supplementation with a Soluble Beta-Glucan Exported from Shiitake Medicinal Mushroom, Lentinus edodes Mycelium: A Crossover, Placebo-Controlled Study in Healthy Elderly. Nutrients. 2024.

20. Lentinan, β-Glucan from Shiitake: A Review on Structure, Conformational Transition, and Gastro-Intestinal Interaction. Food Chem. 2021.

21. Isolation and Comparison of α- and β-D-Glucans from Shiitake Mushrooms (Lentinula edodes) with Different Biological Activities. Carbohydr Polym. 2020.