Bio-Luteolin™ – The new superstar for healthy aging and better absorption

Bio-Luteolin™ from Life Extension is a pioneering dietary supplement with highly bioavailable luteolin. Normal luteolin is poorly absorbed, but by combining pure luteolin (from Japanese Sophora japonica) with galactomannan fibers from fenugreek (fenugreek), absorption increases dramatically - up to 14 times higher total bioavailability and up to 10 times more free (active) luteolin in the blood compared to standard luteolin*. Each vegetable capsule provides 20 mg of pure luteolin in this patented, highly effective form - perfect for those who want maximum support for cell health, brain function and long-term well-being.

The two best-known and best-documented effects of luteolin

• Powerful mast cell stabilizing effect that dampens histamine-related reactions and contributes to a clearer head (especially popular among women aged 30–60).
• Supports a balanced inflammatory response and protects cells against oxidative stress - the basis for healthy ageing.

A surprising and lesser-known effect Luteolin has shown senolytic potential – it helps the body to remove old, dysfunctional "zombie cells" that drive low-grade inflammation and accelerate the aging process.

How Bio-Luteolin™ works Luteolin is a potent flavonoid found in small amounts in celery, thyme, broccoli and chamomile. The biggest challenge has been low absorption in the gut. Life Extension has solved this by encapsulating luteolin into fenugreek-galactomannan fibers that form a protective hydrogel. Clinical studies show significantly higher levels of both total and free luteolin in blood plasma. Luteolin works on several levels:

• Modulates NF-κB, TLR4 and other inflammatory signaling pathways
• Activates protective mechanisms such as Nrf2 and AMPK
• Crosses the blood-brain barrier and supports normal neurobalance
• Acts as an antioxidant at a cellular level without becoming a pro-oxidant in healthy cells

Health benefits

• Supports normal cell function and healthy aging at the cellular level
• Promotes a balanced inflammatory response throughout the body
• Contributes to clarity of mind and good cognitive function over time
• Mast cell stabilizing effect that can alleviate histamine-related challenges
• Protects cells against oxidative stress (general function of flavonoids with antioxidant properties)
• Senolytic support – helps deal with accumulated senescent cells
• Supports brain health, immune balance and general vitality

Grant facts Serving size: 1 vegetable capsule Number of servings per container: 30

Other ingredients Microcrystalline cellulose, vegetable cellulose (capsule), sunflower lecithin, medium-length triglycerides, silica, vegetable stearate. Gluten-free · Non-GMO

Recommended use Take 1 capsule daily, with or without food, or as recommended by a healthcare professional.

Warnings Keep out of the reach of children. Do not exceed the recommended daily dose. Pregnant, breastfeeding or people using medication should consult a doctor before use.

Reservation Allowed to be used by adults. All use of supplements is at your own risk and should be done in consultation with a doctor. The recommended daily dose should not be exceeded. The effect of this product may vary from person to person. Dietary supplements should not replace a varied diet. Should be kept out of the reach of children. Uno Vita AS does not claim that the products we market can cure disease.

Disclaimer Uno Vita increasingly uses artificial intelligence for analyses, summaries and design of articles. We do not accept responsibility for possible errors in texts, articles or descriptions due to human or computer technology (AI) errors, inaccuracies or missing information in scientific and medical studies. We encourage all readers to examine all information critically to ensure that the content is correct. Uno Vita does not claim medical effects of the products we sell, but we refer to publicly available research in accordance with the right to freedom of expression. The information on this website is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment.

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Scientific references

1. Enhanced bioavailability of luteolin utilizing galactomannans (fenugreek fiber) – pharmacokinetic study (2024–2025)
2. Luteolin bioavailability improvement with fenugreek fiber coating – clinical data (Life Extension 2025)
3. Therapeutic Potential of Luteolin in Neurodegenerative Disorders (2025)
4. Luteolin for neurodegenerative diseases: a review (2024)
5. Luteolin, a flavonoid, as an anticancer agent: A review (2024)
6. Therapeutic Potential of Luteolin for Diabetes and Complications (2025)
7. Luteolin rescues postmenopausal osteoporosis via the PI3K-AKT pathway (2025)
8. Dietary luteolin and mortality in CKD patients (2024)
9. Luteolin: A promising multifunctional natural flavonoid (2024)
10. Luteolin antidepressant-like effect via ER stress suppression (2025)
11. Protective effects of luteolin on nephrotoxicity (2024)
12. Luteolin as modulator of skin aging and inflammation (2024)
13. Luteolin inhibits mast cell-mediated allergic inflammation (2024)
14. Impact of polyphenols on mast cells – focus on luteolin (2024)
15. Luteolin inhibits H2O2-induced cellular senescence (2024)
16. Revisiting luteolin: anticancer potential update (2024)
17. Luteolin mitigates brain aging in rats (2024)
18. Palmitoylethanolamide and Luteolin in neuroinflammatory events (2024)
19. Dietary Luteolin reduces proinflammatory microglia in senescent mice (2024)
20. Luteolin therapeutic potentialities and applications (2024)
21. Luteolin in pulmonary diseases – therapeutic role (2025)